Toward a theory‐based specification of non‐pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations

Sietske A. M. Sikkes; Yi Tang; Roos J. Jutten; Linda M. P. Wesselman; Lyn S. Turkstra; Henry Brodaty; Linda Clare; Erin Cassidy-Eagle; Kay L. Cox; Gaël Chételat; Sophie Dautricourt; Klodian Dhana; Hiroko Dodge; Rose-Marie Dröes; Benjamin M. Hampstead; Thomas Holland; Amit Lampit; Kate Laver; Antoine Lutz; Nicola T. Lautenschlager; Susan M. McCurry; Franka J. M. Meiland; Martha Clare Morris; Kimberly D. Mueller; Ruth Peters; Gemma Ridel; Aimee Spector; Jenny T. Steen; Jeanette Tamplin; Zara Thompson; Alex Bahar-Fuchs

doi:10.1002/alz.12188

Toward a theory‐based specification of non‐pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations

Sietske A. M. Sikkes, Yi Tang, Roos J. Jutten, Linda M. P. Wesselman, Lyn S. Turkstra, Henry Brodaty, Linda Clare, Erin Cassidy-Eagle, Kay L. Cox, Gaël Chételat, Sophie Dautricourt, Klodian Dhana, Hiroko Dodge, Rose-Marie Dröes, Benjamin M. Hampstead, Thomas Holland, Amit Lampit, Kate Laver, Antoine Lutz, Nicola T. LautenschlagerSusan M. McCurry, Franka J. M. Meiland, Martha Clare Morris, Kimberly D. Mueller, Ruth Peters, Gemma Ridel, Aimee Spector, Jenny T. Steen, Jeanette Tamplin, Zara Thompson, Alex Bahar-Fuchs

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

7 Downloads (Pure)

Abstract

Introduction:
Non‐pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results.

Methods:
In the current position paper, experts in NPT research have specified treatment targets, aims, and ingredients using an umbrella framework, the Rehabilitation Treatment Specification System.

Results:
Experts provided a snapshot and an authoritative summary of the evidence for different NPTs based on the best synthesis efforts, identified main gaps in knowledge and relevant barriers, and provided directions for future research. Experts in trial methodology provide best practice principles and recommendations for those working in this area, underscoring the importance of prespecified protocols.

Discussion:
We conclude that the evidence strongly supports various NPTs in relation to their primary targets, and discuss opportunities and challenges associated with a unifying theoretical framework to guide future efforts in this area.

Original language	English
Pages (from-to)	255-270
Number of pages	16
Journal	Alzheimer's and Dementia
Volume	17
Issue number	2
Early online date	20 Nov 2020
DOIs	https://doi.org/10.1002/alz.12188
Publication status	Published - Feb 2021

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Cite this

Sikkes, S. A. M., Tang, Y., Jutten, R. J., Wesselman, L. M. P., Turkstra, L. S., Brodaty, H., Clare, L., Cassidy-Eagle, E., Cox, K. L., Chételat, G., Dautricourt, S., Dhana, K., Dodge, H., Dröes, R-M., Hampstead, B. M., Holland, T., Lampit, A., Laver, K., Lutz, A., ... Bahar-Fuchs, A. (2021). Toward a theory‐based specification of non‐pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations. Alzheimer's and Dementia, 17(2), 255-270. https://doi.org/10.1002/alz.12188

@article{0543a71113224d4f938a09982e4dabbb,

title = "Toward a theory‐based specification of non‐pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations",

abstract = "Introduction: Non‐pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results.Methods: In the current position paper, experts in NPT research have specified treatment targets, aims, and ingredients using an umbrella framework, the Rehabilitation Treatment Specification System.Results: Experts provided a snapshot and an authoritative summary of the evidence for different NPTs based on the best synthesis efforts, identified main gaps in knowledge and relevant barriers, and provided directions for future research. Experts in trial methodology provide best practice principles and recommendations for those working in this area, underscoring the importance of prespecified protocols.Discussion: We conclude that the evidence strongly supports various NPTs in relation to their primary targets, and discuss opportunities and challenges associated with a unifying theoretical framework to guide future efforts in this area.",

author = "Sikkes, {Sietske A. M.} and Yi Tang and Jutten, {Roos J.} and Wesselman, {Linda M. P.} and Turkstra, {Lyn S.} and Henry Brodaty and Linda Clare and Erin Cassidy-Eagle and Cox, {Kay L.} and Ga{\"e}l Ch{\'e}telat and Sophie Dautricourt and Klodian Dhana and Hiroko Dodge and Rose-Marie Dr{\"o}es and Hampstead, {Benjamin M.} and Thomas Holland and Amit Lampit and Kate Laver and Antoine Lutz and Lautenschlager, {Nicola T.} and McCurry, {Susan M.} and Meiland, {Franka J. M.} and Morris, {Martha Clare} and Mueller, {Kimberly D.} and Ruth Peters and Gemma Ridel and Aimee Spector and Steen, {Jenny T.} and Jeanette Tamplin and Zara Thompson and Alex Bahar-Fuchs",

year = "2021",

month = feb,

doi = "10.1002/alz.12188",

language = "English",

volume = "17",

pages = "255--270",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

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Sikkes, SAM, Tang, Y, Jutten, RJ, Wesselman, LMP, Turkstra, LS, Brodaty, H, Clare, L, Cassidy-Eagle, E, Cox, KL, Chételat, G, Dautricourt, S, Dhana, K, Dodge, H, Dröes, R-M, Hampstead, BM, Holland, T, Lampit, A, Laver, K, Lutz, A, Lautenschlager, NT, McCurry, SM, Meiland, FJM, Morris, MC, Mueller, KD, Peters, R, Ridel, G, Spector, A, Steen, JT, Tamplin, J, Thompson, Z & Bahar-Fuchs, A 2021, 'Toward a theory‐based specification of non‐pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations', Alzheimer's and Dementia, vol. 17, no. 2, pp. 255-270. https://doi.org/10.1002/alz.12188

TY - JOUR

T1 - Toward a theory‐based specification of non‐pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations

AU - Sikkes, Sietske A. M.

AU - Tang, Yi

AU - Jutten, Roos J.

AU - Wesselman, Linda M. P.

AU - Turkstra, Lyn S.

AU - Brodaty, Henry

AU - Clare, Linda

AU - Cassidy-Eagle, Erin

AU - Cox, Kay L.

AU - Chételat, Gaël

AU - Dautricourt, Sophie

AU - Dhana, Klodian

AU - Dodge, Hiroko

AU - Dröes, Rose-Marie

AU - Hampstead, Benjamin M.

AU - Holland, Thomas

AU - Lampit, Amit

AU - Laver, Kate

AU - Lutz, Antoine

AU - Lautenschlager, Nicola T.

AU - McCurry, Susan M.

AU - Meiland, Franka J. M.

AU - Morris, Martha Clare

AU - Mueller, Kimberly D.

AU - Peters, Ruth

AU - Ridel, Gemma

AU - Spector, Aimee

AU - Steen, Jenny T.

AU - Tamplin, Jeanette

AU - Thompson, Zara

AU - Bahar-Fuchs, Alex

PY - 2021/2

Y1 - 2021/2

N2 - Introduction: Non‐pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results.Methods: In the current position paper, experts in NPT research have specified treatment targets, aims, and ingredients using an umbrella framework, the Rehabilitation Treatment Specification System.Results: Experts provided a snapshot and an authoritative summary of the evidence for different NPTs based on the best synthesis efforts, identified main gaps in knowledge and relevant barriers, and provided directions for future research. Experts in trial methodology provide best practice principles and recommendations for those working in this area, underscoring the importance of prespecified protocols.Discussion: We conclude that the evidence strongly supports various NPTs in relation to their primary targets, and discuss opportunities and challenges associated with a unifying theoretical framework to guide future efforts in this area.

AB - Introduction: Non‐pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results.Methods: In the current position paper, experts in NPT research have specified treatment targets, aims, and ingredients using an umbrella framework, the Rehabilitation Treatment Specification System.Results: Experts provided a snapshot and an authoritative summary of the evidence for different NPTs based on the best synthesis efforts, identified main gaps in knowledge and relevant barriers, and provided directions for future research. Experts in trial methodology provide best practice principles and recommendations for those working in this area, underscoring the importance of prespecified protocols.Discussion: We conclude that the evidence strongly supports various NPTs in relation to their primary targets, and discuss opportunities and challenges associated with a unifying theoretical framework to guide future efforts in this area.

U2 - 10.1002/alz.12188

DO - 10.1002/alz.12188

M3 - Article

VL - 17

SP - 255

EP - 270

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

IS - 2

ER -