Towards a total synthesis of the manadomanzamine alkaloids: the first asymmetric construction of the pentacyclic indole core

S. M. Allin, L. J. Duffy, P. C. B. Bulman Page, V. McKee, M. J. McKenzie

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We report a highly diastereoselective approach for the synthesis of the pentacyclic indole core of the manadomanzamine alkaloid skeleton, with complete control over the relative and absolute stereochemistries at the three contiguous stereocentres at ring positions 1, 10, and 24, from a readily available chiral template. Crown Copyright (c) 2007 Published by Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)4711-4714
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number27
DOIs
Publication statusPublished - 2 Jul 2007

Keywords

  • HIGHLY STEREOSELECTIVE-SYNTHESIS
  • NATURAL-PRODUCT SYNTHESIS
  • DERIVATIVES
  • ENANTIOMERS
  • PYRROLOISOQUINOLINE RING-SYSTEM
  • FACILE
  • TEMPLATES

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