Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease

Jochen Springer, Frank R Scholz, Christian Peiser, Q Thai Dinh, Axel Fischer, David Quarcoo, David A Groneberg

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Abstract

Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD). Suppressor of cytokine signaling (SOCS) family members are involved in the pathogenesis of many inflammatory diseases and SOCS-3 has been shown to play an important role in the regulation, onset and maintenance of airway allergic inflammation indicating that SOCS-3 displays a potential therapeutic target for anti-inflammatory respiratory drugs development. Since chronic obstructive pulmonary disease (COPD) is also characterized by inflammatory changes and airflow limitation, the present study assessed the transcriptional expression of SOCS-3 in COPD.
Original languageEnglish
Pages (from-to)29
JournalJournal of Occupational Medicine and Toxicology
Volume8
Issue number1
DOIs
Publication statusPublished - 18 Oct 2013

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