Transdiagnostic associations across communication, cognitive, and behavioural problems in a developmentally at-risk population: A network approach

Silvana Mareva, The CALM Team , Joni Holmes

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: Communication, behavioural, and executive function problems often co-occur in childhood. Previous attempts to identify the origins of these comorbidities have typically relied on comparisons of different deficit groups and/or latent variable models. Here we apply a network approach to a heterogeneous sample of struggling learners to conceptualise these comorbidities as a dynamic system of interacting difficulties. 

Methods: 714 children struggling with attention, learning, and/or memory were included. The sample consisted of children with both diagnosed (41%) and undiagnosed difficulties. The conditional independence network of parent ratings of everyday behaviour, cognition, and communication was estimated. 

Results: A clustering coefficient identified four interconnected areas of difficulty: (1) structural language and learning; (2) pragmatics and peer relationships; (3) behavioural and emotional problems; and (4) cognitive skills. Emotional and behavioural symptoms shared multiple direct connections with pragmatic abilities and cognitive problems, but not with structural language skills or learning problems. Poor structural language and cognitive skills were associated with learning problems. Centrality indices highlighted working memory and language coherence as symptoms bridging different problem areas. 

Conclusion: The network model identified four areas of difficulty and potential bridging symptoms. Although the current analytic framework does not provide causal evidence, it is possible that bridging symptoms may be the origins of comorbidities observed on a dimensional level; problems in these areas may cascade and activate problems in other areas of the network. The potential value of applying a dynamic systems network approach to symptoms of developmental disorders is discussed.

Original languageEnglish
Article number452
Number of pages12
JournalBMC Pediatrics
Volume19
Issue number1
DOIs
Publication statusPublished - 21 Nov 2019

Keywords

  • ADHD
  • Language
  • Executive function
  • Learning difficulties
  • Behaviour problems
  • Network analysis
  • ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
  • WORKING-MEMORY
  • LANGUAGE IMPAIRMENT
  • EXECUTIVE FUNCTION
  • ADHD TRAITS
  • CHILDREN
  • COMORBIDITY
  • HYPERACTIVITY
  • SKILLS
  • CLASSIFICATION

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