Transmission events within outbreaks of gastroenteritis determined through analysis of nucleotide sequences of the P2 domain of genogroup II noroviruses

Jacqueline Xerry; Chris I. Gallimore; Miren Iturriza-Gómara; David J. Allen; Jim J. Gray

doi:10.1128/JCM.02240-07

Transmission events within outbreaks of gastroenteritis determined through analysis of nucleotide sequences of the P2 domain of genogroup II noroviruses

Jacqueline Xerry, Chris I. Gallimore, Miren Iturriza-Gómara, David J. Allen, Jim J. Gray

Norwich Medical School

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Abstract

Tracking the spread of noroviruses during outbreaks of gastroenteritis is hampered by the lack of sequence diversity in those regions of the genome chosen for virus detection and characterization. Sequence analysis of regions of the genes encoding the RNA-dependent RNA polymerase and the S domain of the capsid does not provide sufficient discrimination between genotypically related strains of different outbreaks. However, analysis of sequences derived from the region encoding the P2 domain showed 100% similarity among strains from the same outbreak and

Original language	English
Pages (from-to)	947-953
Number of pages	7
Journal	Journal of Clinical Microbiology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1128/JCM.02240-07
Publication status	Published - Mar 2008

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10.1128/JCM.02240-07

Cite this

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abstract = "Tracking the spread of noroviruses during outbreaks of gastroenteritis is hampered by the lack of sequence diversity in those regions of the genome chosen for virus detection and characterization. Sequence analysis of regions of the genes encoding the RNA-dependent RNA polymerase and the S domain of the capsid does not provide sufficient discrimination between genotypically related strains of different outbreaks. However, analysis of sequences derived from the region encoding the P2 domain showed 100% similarity among strains from the same outbreak and ",

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AU - Allen, David J.

AU - Gray, Jim J.

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