Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni

Emanuele Fabbrizi; Gebremedhin Solomon Hailu; A. Ganesan; Rossella Fioravanti; Clemens Zwergel; Chiara Lambona; Sergio Valente; Giulia Fianco; Angela Iuzzolino; Daniela Trisciuoglio; Jonatan Caroli; Andrea Mattevi; Cécile Häberli; Jennifer Keiser; Dante Rotili; Antonello Mai

doi:10.1021/acsinfecdis.5c00224

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni

Emanuele Fabbrizi
, Gebremedhin Solomon Hailu
, A. Ganesan
, Rossella Fioravanti
, Clemens Zwergel
, Chiara Lambona
, Sergio Valente
, Giulia Fianco
, Angela Iuzzolino
, Daniela Trisciuoglio
, Jonatan Caroli
, Andrea Mattevi
, Cécile Häberli
, Jennifer Keiser
, Dante Rotili
, Antonello Mai

School of Chemistry, Pharmacy and Pharmacology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Schistosoma infections remain a major public health issue mainly in tropical and subtropical regions. While Praziquantel is the primary treatment for schistosomiasis, its limitations include resistance development and poor efficacy against juvenile worms. Given the biological similarities between tumor and parasite-infected cells, LSD1 inhibitors─primarily explored as anticancer agents─have been investigated for their antiparasitic potential.

Original language	English
Pages (from-to)	2178-2189
Number of pages	12
Journal	ACS Infectious Diseases
Volume	11
Issue number	8
DOIs	https://doi.org/10.1021/acsinfecdis.5c00224
Publication status	Published - 2 Jul 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cytotoxicity
LSD1
lysine demethylases
reduction of viability
S. mansoni

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10.1021/acsinfecdis.5c00224Licence: CC BY

tranylcypromine-based-lsd1-inhibitors-as-useful-agents-to-reduce-viability-of-schistosoma-mansoniFinal published version, 2.14 MBLicence: CC BY

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Fabbrizi, E., Hailu, G. S., Ganesan, A., Fioravanti, R., Zwergel, C., Lambona, C., Valente, S., Fianco, G., Iuzzolino, A., Trisciuoglio, D., Caroli, J., Mattevi, A., Häberli, C., Keiser, J., Rotili, D., & Mai, A. (2025). Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni. ACS Infectious Diseases, 11(8), 2178-2189. https://doi.org/10.1021/acsinfecdis.5c00224

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abstract = "Schistosoma infections remain a major public health issue mainly in tropical and subtropical regions. While Praziquantel is the primary treatment for schistosomiasis, its limitations include resistance development and poor efficacy against juvenile worms. Given the biological similarities between tumor and parasite-infected cells, LSD1 inhibitors─primarily explored as anticancer agents─have been investigated for their antiparasitic potential.",

keywords = "cytotoxicity, LSD1, lysine demethylases, reduction of viability, S. mansoni",

author = "Emanuele Fabbrizi and Hailu, \{Gebremedhin Solomon\} and A. Ganesan and Rossella Fioravanti and Clemens Zwergel and Chiara Lambona and Sergio Valente and Giulia Fianco and Angela Iuzzolino and Daniela Trisciuoglio and Jonatan Caroli and Andrea Mattevi and C{\'e}cile H{\"a}berli and Jennifer Keiser and Dante Rotili and Antonello Mai",

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doi = "10.1021/acsinfecdis.5c00224",

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Fabbrizi, E, Hailu, GS, Ganesan, A, Fioravanti, R, Zwergel, C, Lambona, C, Valente, S, Fianco, G, Iuzzolino, A, Trisciuoglio, D, Caroli, J, Mattevi, A, Häberli, C, Keiser, J, Rotili, D & Mai, A 2025, 'Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni', ACS Infectious Diseases, vol. 11, no. 8, pp. 2178-2189. https://doi.org/10.1021/acsinfecdis.5c00224

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T1 - Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni

AU - Fabbrizi, Emanuele

AU - Hailu, Gebremedhin Solomon

AU - Ganesan, A.

AU - Fioravanti, Rossella

AU - Zwergel, Clemens

AU - Lambona, Chiara

AU - Valente, Sergio

AU - Fianco, Giulia

AU - Iuzzolino, Angela

AU - Trisciuoglio, Daniela

AU - Caroli, Jonatan

AU - Mattevi, Andrea

AU - Häberli, Cécile

AU - Keiser, Jennifer

AU - Rotili, Dante

AU - Mai, Antonello

PY - 2025/7/2

Y1 - 2025/7/2

N2 - Schistosoma infections remain a major public health issue mainly in tropical and subtropical regions. While Praziquantel is the primary treatment for schistosomiasis, its limitations include resistance development and poor efficacy against juvenile worms. Given the biological similarities between tumor and parasite-infected cells, LSD1 inhibitors─primarily explored as anticancer agents─have been investigated for their antiparasitic potential.

AB - Schistosoma infections remain a major public health issue mainly in tropical and subtropical regions. While Praziquantel is the primary treatment for schistosomiasis, its limitations include resistance development and poor efficacy against juvenile worms. Given the biological similarities between tumor and parasite-infected cells, LSD1 inhibitors─primarily explored as anticancer agents─have been investigated for their antiparasitic potential.

KW - cytotoxicity

KW - LSD1

KW - lysine demethylases

KW - reduction of viability

KW - S. mansoni

UR - https://www.scopus.com/pages/publications/105009607477

U2 - 10.1021/acsinfecdis.5c00224

DO - 10.1021/acsinfecdis.5c00224

M3 - Article

C2 - 40601861

AN - SCOPUS:105009607477

SN - 2373-8227

VL - 11

SP - 2178

EP - 2189

JO - ACS Infectious Diseases

JF - ACS Infectious Diseases

IS - 8

ER -

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni

Abstract

UN SDGs

Keywords

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