Treadmill training for individuals with multiple sclerosis: a pilot randomised trial

M van den Berg, H Dawes, D T Wade, M Newman, J Burridge, H Izadi, C M Sackley

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145 Citations (Scopus)


This pilot study investigated whether 4 weeks of aerobic treadmill training in individuals with multiple sclerosis (MS) improved mobility and reduced fatigue. Individuals with MS were recruited to this prospective, randomised controlled trial. Individuals were assessed at baseline, week 7 and 12 with a 10 metre timed walk, a 2 minute walk, the Rivermead Mobility Index, and the Fatigue Severity Scale. After a pre-assessment familiarisation session and a baseline assessment, individuals were randomly allocated to an initial intervention or delayed intervention group. Treadmill training consisted of 4 weeks of supervised aerobic exercise delivered weeks 3-6 in the immediate group and 8-11 in the delayed group. Of the initial 19 recruits, 16 individuals completed the study. There was a significant difference in walking endurance between the delayed and immediate groups at baseline (p
Original languageEnglish
Pages (from-to)531-533
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number4
Publication statusPublished - Apr 2006


  • Severity of Illness Index
  • Fatigue
  • Humans
  • Physical Fitness
  • Aged
  • Exercise
  • Exercise Test
  • Multiple Sclerosis
  • Prospective Studies
  • Adult
  • Follow-Up Studies
  • Middle Aged
  • Time Factors
  • Female
  • Male

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