Treatment-related change versus tumor recurrence in high-grade gliomas: a diagnostic conundrum--use of dynamic susceptibility contrast-enhanced (DSC) perfusion MRI

Girish M. Fatterpekar, Diogo Galheigo, Ashwatha Narayana, Glyn Johnson, Edmond Knopp

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OBJECTIVE: The purpose of this article is to address radiation necrosis, pseudoprogression, and pseudoresponse relative to high-grade gliomas and evaluate the role of conventional MRI and, in particular, dynamic susceptibility contrast-enhanced perfusion MRI in assessing such treatment-related changes from tumor recurrence. CONCLUSION: Posttreatment imaging assessment of high-grade gliomas remains challenging. Familiarity with the expected MR imaging appearances of treatment-related change and tumor recurrence will help distinguish these entities allowing appropriate management.
Original languageEnglish
Pages (from-to)19-26
JournalAmerican Journal of Roentgenology
Issue number1
Publication statusPublished - Jan 2012


  • perfusion
  • pseudoprogression
  • pseudoresponse
  • radiation necrosis
  • tumor recurrence

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