Treatment-related change versus tumor recurrence in high-grade gliomas: a diagnostic conundrum--use of dynamic susceptibility contrast-enhanced (DSC) perfusion MRI

Girish M. Fatterpekar; Diogo Galheigo; Ashwatha Narayana; Glyn Johnson; Edmond Knopp

doi:10.2214/AJR.11.7417

Treatment-related change versus tumor recurrence in high-grade gliomas: a diagnostic conundrum--use of dynamic susceptibility contrast-enhanced (DSC) perfusion MRI

Girish M. Fatterpekar, Diogo Galheigo, Ashwatha Narayana, Glyn Johnson, Edmond Knopp

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this article is to address radiation necrosis, pseudoprogression, and pseudoresponse relative to high-grade gliomas and evaluate the role of conventional MRI and, in particular, dynamic susceptibility contrast-enhanced perfusion MRI in assessing such treatment-related changes from tumor recurrence. CONCLUSION: Posttreatment imaging assessment of high-grade gliomas remains challenging. Familiarity with the expected MR imaging appearances of treatment-related change and tumor recurrence will help distinguish these entities allowing appropriate management.

Original language	English
Pages (from-to)	19-26
Journal	American Journal of Roentgenology
Volume	198
Issue number	1
DOIs	https://doi.org/10.2214/AJR.11.7417
Publication status	Published - Jan 2012

Keywords

perfusion
pseudoprogression
pseudoresponse
radiation necrosis
tumor recurrence

Access to Document

10.2214/AJR.11.7417

Cite this

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abstract = "OBJECTIVE: The purpose of this article is to address radiation necrosis, pseudoprogression, and pseudoresponse relative to high-grade gliomas and evaluate the role of conventional MRI and, in particular, dynamic susceptibility contrast-enhanced perfusion MRI in assessing such treatment-related changes from tumor recurrence. CONCLUSION: Posttreatment imaging assessment of high-grade gliomas remains challenging. Familiarity with the expected MR imaging appearances of treatment-related change and tumor recurrence will help distinguish these entities allowing appropriate management.",

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In: American Journal of Roentgenology, Vol. 198, No. 1, 01.2012, p. 19-26.

Research output: Contribution to journal › Article › peer-review

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AU - Fatterpekar, Girish M.

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AB - OBJECTIVE: The purpose of this article is to address radiation necrosis, pseudoprogression, and pseudoresponse relative to high-grade gliomas and evaluate the role of conventional MRI and, in particular, dynamic susceptibility contrast-enhanced perfusion MRI in assessing such treatment-related changes from tumor recurrence. CONCLUSION: Posttreatment imaging assessment of high-grade gliomas remains challenging. Familiarity with the expected MR imaging appearances of treatment-related change and tumor recurrence will help distinguish these entities allowing appropriate management.

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KW - pseudoprogression

KW - pseudoresponse

KW - radiation necrosis

KW - tumor recurrence

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