Trends in childhood tuberculosis in Zambia: A situation analysis

Nathan Kapata; Pascalina Chanda-Kapata; Justin O'Grady; Matthew Bates; Peter Mwaba; Saskia Janssen; Ben Marais; Frank Cobelens; Martin Grobusch; Alimuddin Zumla

doi:10.1093/tropej/fms065

Trends in childhood tuberculosis in Zambia: A situation analysis

Nathan Kapata, Pascalina Chanda-Kapata, Justin O'Grady, Matthew Bates, Peter Mwaba, Saskia Janssen, Ben Marais, Frank Cobelens, Martin Grobusch, Alimuddin Zumla

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Objectives: To ascertain childhood tuberculosis (TB) trends, human immunodeficiency virus (HIV) co-infection rates and multi-drug resistant TB (MDR-TB) prevalence rates in Zambia.

Methods: A retrospective review of Zambian annual TB notification data and National TB Programme reports for a 7 year period (2004–2011). TB trends were stratified by age and HIV status.

Results: The total number of children notified during this period with all forms of TB was 40 976. A total of 2670 of 40 976 (6%) were smear-positive cases. Notification rates of all forms of childhood TB show a decline in trends from 135 per 100 000 population in 2004, to 69 per 100 000 population in 2011.

Conclusions: Childhood TB is an important but neglected problem in Zambia highlighted by the fact that no data exists on HIV co-infection and MDR-TB. Strengthening of the National TB Programme and diagnostics services/algorithms are required to accurately define the TB burden, HIV co-infection and MDR-TB rates in children in Zambia.

Original language	English
Pages (from-to)	134-139
Number of pages	6
Journal	Journal of Tropical Pediatrics
Volume	59
Issue number	2
Early online date	12 Dec 2012
DOIs	https://doi.org/10.1093/tropej/fms065
Publication status	Published - 2013

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10.1093/tropej/fms065

Cite this

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title = "Trends in childhood tuberculosis in Zambia: A situation analysis",

abstract = "Objectives: To ascertain childhood tuberculosis (TB) trends, human immunodeficiency virus (HIV) co-infection rates and multi-drug resistant TB (MDR-TB) prevalence rates in Zambia. Methods: A retrospective review of Zambian annual TB notification data and National TB Programme reports for a 7 year period (2004–2011). TB trends were stratified by age and HIV status. Results: The total number of children notified during this period with all forms of TB was 40 976. A total of 2670 of 40 976 (6%) were smear-positive cases. Notification rates of all forms of childhood TB show a decline in trends from 135 per 100 000 population in 2004, to 69 per 100 000 population in 2011. Conclusions: Childhood TB is an important but neglected problem in Zambia highlighted by the fact that no data exists on HIV co-infection and MDR-TB. Strengthening of the National TB Programme and diagnostics services/algorithms are required to accurately define the TB burden, HIV co-infection and MDR-TB rates in children in Zambia.",

author = "Nathan Kapata and Pascalina Chanda-Kapata and Justin O'Grady and Matthew Bates and Peter Mwaba and Saskia Janssen and Ben Marais and Frank Cobelens and Martin Grobusch and Alimuddin Zumla",

year = "2013",

doi = "10.1093/tropej/fms065",

language = "English",

volume = "59",

pages = "134--139",

journal = "Journal of Tropical Pediatrics",

issn = "0142-6338",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Trends in childhood tuberculosis in Zambia: A situation analysis

AU - Kapata, Nathan

AU - Chanda-Kapata, Pascalina

AU - O'Grady, Justin

AU - Bates, Matthew

AU - Mwaba, Peter

AU - Janssen, Saskia

AU - Marais, Ben

AU - Cobelens, Frank

AU - Grobusch, Martin

AU - Zumla, Alimuddin

PY - 2013

Y1 - 2013

N2 - Objectives: To ascertain childhood tuberculosis (TB) trends, human immunodeficiency virus (HIV) co-infection rates and multi-drug resistant TB (MDR-TB) prevalence rates in Zambia. Methods: A retrospective review of Zambian annual TB notification data and National TB Programme reports for a 7 year period (2004–2011). TB trends were stratified by age and HIV status. Results: The total number of children notified during this period with all forms of TB was 40 976. A total of 2670 of 40 976 (6%) were smear-positive cases. Notification rates of all forms of childhood TB show a decline in trends from 135 per 100 000 population in 2004, to 69 per 100 000 population in 2011. Conclusions: Childhood TB is an important but neglected problem in Zambia highlighted by the fact that no data exists on HIV co-infection and MDR-TB. Strengthening of the National TB Programme and diagnostics services/algorithms are required to accurately define the TB burden, HIV co-infection and MDR-TB rates in children in Zambia.

AB - Objectives: To ascertain childhood tuberculosis (TB) trends, human immunodeficiency virus (HIV) co-infection rates and multi-drug resistant TB (MDR-TB) prevalence rates in Zambia. Methods: A retrospective review of Zambian annual TB notification data and National TB Programme reports for a 7 year period (2004–2011). TB trends were stratified by age and HIV status. Results: The total number of children notified during this period with all forms of TB was 40 976. A total of 2670 of 40 976 (6%) were smear-positive cases. Notification rates of all forms of childhood TB show a decline in trends from 135 per 100 000 population in 2004, to 69 per 100 000 population in 2011. Conclusions: Childhood TB is an important but neglected problem in Zambia highlighted by the fact that no data exists on HIV co-infection and MDR-TB. Strengthening of the National TB Programme and diagnostics services/algorithms are required to accurately define the TB burden, HIV co-infection and MDR-TB rates in children in Zambia.

U2 - 10.1093/tropej/fms065

DO - 10.1093/tropej/fms065

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SP - 134

EP - 139

JO - Journal of Tropical Pediatrics

JF - Journal of Tropical Pediatrics

SN - 0142-6338

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ER -