Truncated azinomycin analogues intercalate into DNA

M. A. Casely-Hayford, K. Pors, L. H. Patterson, C. Gerner, S. Neidle, M. Searcey

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. (C) 2004 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)653-656
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Issue number3
Publication statusPublished - 2005

Cite this