Truncated azinomycin analogues intercalate into DNA

M. A. Casely-Hayford; K. Pors; L. H. Patterson; C. Gerner; S. Neidle; M. Searcey

doi:10.1016/j.bmcl.2004.11.037

Truncated azinomycin analogues intercalate into DNA

M. A. Casely-Hayford, K. Pors, L. H. Patterson, C. Gerner, S. Neidle, M. Searcey

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Abstract

The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. (C) 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	653-656
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2004.11.037
Publication status	Published - 2005

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10.1016/j.bmcl.2004.11.037

Cite this

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title = "Truncated azinomycin analogues intercalate into DNA",

abstract = "The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. (C) 2004 Elsevier Ltd. All rights reserved.",

author = "Casely-Hayford, {M. A.} and K. Pors and Patterson, {L. H.} and C. Gerner and S. Neidle and M. Searcey",

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T1 - Truncated azinomycin analogues intercalate into DNA

AU - Casely-Hayford, M. A.

AU - Pors, K.

AU - Patterson, L. H.

AU - Gerner, C.

AU - Neidle, S.

AU - Searcey, M.

PY - 2005

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AB - The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. (C) 2004 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.bmcl.2004.11.037

DO - 10.1016/j.bmcl.2004.11.037

M3 - Article

SN - 0960-894X

VL - 15

SP - 653

EP - 656

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 3

ER -