Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling

Dietmar Steverding; Darren W. Sexton

doi:10.1186/1756-3305-6-78

Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling

Dietmar Steverding, Darren W. Sexton

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The few currently available drugs for treatment of African trypanosomiasis are outdated and show problems with toxicity and resistance. Hence, there is an urgent need for the discovery and development of new anti-trypanosomal agents.

Original language	English
Article number	78
Journal	Parasites & Vectors
Volume	6
DOIs	https://doi.org/10.1186/1756-3305-6-78
Publication status	Published - 21 Mar 2013

Keywords

Antiprotozoal Agents
Inhibitory Concentration 50
Osmotic Pressure
Pyrans
Sodium
Trypanosoma brucei brucei

Access to Document

10.1186/1756-3305-6-78Licence: CC BY

Cite this

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title = "Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling",

abstract = "The few currently available drugs for treatment of African trypanosomiasis are outdated and show problems with toxicity and resistance. Hence, there is an urgent need for the discovery and development of new anti-trypanosomal agents.",

keywords = "Antiprotozoal Agents, Inhibitory Concentration 50, Osmotic Pressure, Pyrans, Sodium, Trypanosoma brucei brucei",

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KW - Pyrans

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