TY - JOUR
T1 - Trypanosoma evansi: demonstration of a transferrin receptor derived from expression site-associated genes 6 and 7
AU - Kabiri, Mostafa
AU - Steverding, Dietmar
PY - 2001
Y1 - 2001
N2 - In Trypanosoma brucei, uptake of host transferrin is mediated by a heterodimeric, glycosylphosphatidylinositol-anchored receptor derived from the 2 expression site-associated genes 6 and 7 (ESAG6 and ESAG7). By using specific antibodies, it is shown here that T. evansi, a trypanosome species transmitted mechanically by biting flies, also expresses a transferrin receptor composed of ESAG6 and ESAG7. The cellular uptake of transferrin in T. evansi is completely inhibited with anti-T. brucei (ESAG6/7 heterodimer) antibodies. The demonstration of a functional ESAG6/7 transferrin receptor in T. evansi supports further its close relationship to T. brucei.
AB - In Trypanosoma brucei, uptake of host transferrin is mediated by a heterodimeric, glycosylphosphatidylinositol-anchored receptor derived from the 2 expression site-associated genes 6 and 7 (ESAG6 and ESAG7). By using specific antibodies, it is shown here that T. evansi, a trypanosome species transmitted mechanically by biting flies, also expresses a transferrin receptor composed of ESAG6 and ESAG7. The cellular uptake of transferrin in T. evansi is completely inhibited with anti-T. brucei (ESAG6/7 heterodimer) antibodies. The demonstration of a functional ESAG6/7 transferrin receptor in T. evansi supports further its close relationship to T. brucei.
U2 - 10.1645/0022-3395(2001)087[1189:TEDOAT]2.0.CO;2
DO - 10.1645/0022-3395(2001)087[1189:TEDOAT]2.0.CO;2
M3 - Article
VL - 87
SP - 1189
EP - 1191
JO - Journal of Parasitology
JF - Journal of Parasitology
SN - 0022-3395
IS - 5
ER -