Trypanosoma evansi: demonstration of a transferrin receptor derived from expression site-associated genes 6 and 7

M Kabiri, D Steverding

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Abstract

In Trypanosoma brucei, uptake of host transferrin is mediated by a heterodimeric, glycosylphosphatidylinositol-anchored receptor derived from the 2 expression site-associated genes 6 and 7 (ESAG6 and ESAG7). By using specific antibodies, it is shown here that T. evansi, a trypanosome species transmitted mechanically by biting flies, also expresses a transferrin receptor composed of ESAG6 and ESAG7. The cellular uptake of transferrin in T. evansi is completely inhibited with anti-T. brucei (ESAG6/7 heterodimer) antibodies. The demonstration of a functional ESAG6/7 transferrin receptor in T. evansi supports further its close relationship to T. brucei.
Original languageEnglish
Pages (from-to)1189-1191
Number of pages3
JournalJournal of Parasitology
Volume87
Issue number5
Publication statusPublished - 2001

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