Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study

Emilie Lalonde, Adrian S Ishkanian, Jenna Sykes, Michael Fraser, Helen Ross-Adams, Nicholas Erho, Mark J Dunning, Silvia Halim, Alastair D Lamb, Nathalie C Moon, Gaetano Zafarana, Anne Y Warren, Xianyue Meng, John Thoms, Michal R Grzadkowski, Alejandro Berlin, Cherry L Have, Varune R Ramnarine, Cindy Q Yao, Chad A MalloffColin Cooper

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Abstract

Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.
Original languageEnglish
Pages (from-to)1521–1532
Number of pages12
JournalThe Lancet Oncology
Volume15
Issue number13
Early online date13 Nov 2014
DOIs
Publication statusPublished - Dec 2014

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