Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study

Emilie Lalonde, Adrian S. Ishkanian, Jenna Sykes, Michael Fraser, Helen Ross-Adams, Nicholas Erho, Mark J. Dunning, Silvia Halim, Alastair D. Lamb, Nathalie C. Moon, Gaetano Zafarana, Anne Y. Warren, Xianyue Meng, John Thoms, Michal R. Grzadkowski, Alejandro Berlin, Cherry L. Have, Varune R. Ramnarine, Cindy Q. Yao, Chad A. MalloffLucia L. Lam, Honglei Xie, Nicholas J. Harding, Denise Y. F. Mak, Kenneth C. Chu, Lauren C. Chong, Dorota H. Sendorek, Christine P'ng, Colin C. Collins, Jeremy A. Squire, Igor Jurisica, Colin Cooper, Rosalind Eeles, Melania Pintilie, Alan Dal Pra, Elai Davicioni, Wan L. Lam, Michael Milosevic, David E. Neal, Theodorus van der Kwast, Paul C. Boutros, Robert G. Bristow

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Abstract

Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.
Original languageEnglish
Pages (from-to)1521–1532
Number of pages12
JournalThe Lancet Oncology
Volume15
Issue number13
Early online date13 Nov 2014
DOIs
Publication statusPublished - Dec 2014

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