Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study

Emilie Lalonde; Adrian S Ishkanian; Jenna Sykes; Michael Fraser; Helen Ross-Adams; Nicholas Erho; Mark J Dunning; Silvia Halim; Alastair D Lamb; Nathalie C Moon; Gaetano Zafarana; Anne Y Warren; Xianyue Meng; John  Thoms; Michal R Grzadkowski; Alejandro Berlin; Cherry L Have; Varune R Ramnarine; Cindy Q Yao; Chad A Malloff; Colin Cooper

doi:10.1016/S1470-2045(14)71021-6

Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study

Emilie Lalonde, Adrian S Ishkanian, Jenna Sykes, Michael Fraser, Helen Ross-Adams, Nicholas Erho, Mark J Dunning, Silvia Halim, Alastair D Lamb, Nathalie C Moon, Gaetano Zafarana, Anne Y Warren, Xianyue Meng, John Thoms, Michal R Grzadkowski, Alejandro Berlin, Cherry L Have, Varune R Ramnarine, Cindy Q Yao, Chad A MalloffColin Cooper

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Abstract

Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.

Original language	English
Pages (from-to)	1521–1532
Number of pages	12
Journal	The Lancet Oncology
Volume	15
Issue number	13
Early online date	13 Nov 2014
DOIs	https://doi.org/10.1016/S1470-2045(14)71021-6
Publication status	Published - Dec 2014

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Lalonde, E., Ishkanian, A. S., Sykes, J., Fraser, M., Ross-Adams, H., Erho, N., Dunning, M. J., Halim, S., Lamb, A. D., Moon, N. C., Zafarana, G., Warren, A. Y., Meng, X., Thoms, J., Grzadkowski, M. R., Berlin, A., Have, C. L., Ramnarine, V. R., Yao, C. Q., ... Cooper, C. (2014). Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study. The Lancet Oncology, 15(13), 1521–1532. https://doi.org/10.1016/S1470-2045(14)71021-6

Lalonde, Emilie ; Ishkanian, Adrian S ; Sykes, Jenna ; Fraser, Michael ; Ross-Adams, Helen ; Erho, Nicholas ; Dunning, Mark J ; Halim, Silvia ; Lamb, Alastair D ; Moon, Nathalie C ; Zafarana, Gaetano ; Warren, Anne Y ; Meng, Xianyue ; Thoms, John ; Grzadkowski, Michal R ; Berlin, Alejandro ; Have, Cherry L ; Ramnarine, Varune R ; Yao, Cindy Q ; Malloff, Chad A ; Cooper, Colin. / Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study. In: The Lancet Oncology. 2014 ; Vol. 15, No. 13. pp. 1521–1532.

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title = "Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study",

abstract = "Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.",

author = "Emilie Lalonde and Ishkanian, {Adrian S} and Jenna Sykes and Michael Fraser and Helen Ross-Adams and Nicholas Erho and Dunning, {Mark J} and Silvia Halim and Lamb, {Alastair D} and Moon, {Nathalie C} and Gaetano Zafarana and Warren, {Anne Y} and Xianyue Meng and John Thoms and Grzadkowski, {Michal R} and Alejandro Berlin and Have, {Cherry L} and Ramnarine, {Varune R} and Yao, {Cindy Q} and Malloff, {Chad A} and Colin Cooper",

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Lalonde, E, Ishkanian, AS, Sykes, J, Fraser, M, Ross-Adams, H, Erho, N, Dunning, MJ, Halim, S, Lamb, AD, Moon, NC, Zafarana, G, Warren, AY, Meng, X, Thoms, J, Grzadkowski, MR, Berlin, A, Have, CL, Ramnarine, VR, Yao, CQ, Malloff, CA & Cooper, C 2014, 'Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study', The Lancet Oncology, vol. 15, no. 13, pp. 1521–1532. https://doi.org/10.1016/S1470-2045(14)71021-6

Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study. / Lalonde, Emilie; Ishkanian, Adrian S; Sykes, Jenna; Fraser, Michael; Ross-Adams, Helen; Erho, Nicholas; Dunning, Mark J; Halim, Silvia; Lamb, Alastair D; Moon, Nathalie C; Zafarana, Gaetano; Warren, Anne Y; Meng, Xianyue; Thoms, John ; Grzadkowski, Michal R; Berlin, Alejandro; Have, Cherry L; Ramnarine, Varune R; Yao, Cindy Q; Malloff, Chad A; Cooper, Colin.

In: The Lancet Oncology, Vol. 15, No. 13, 12.2014, p. 1521–1532.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study

AU - Lalonde, Emilie

AU - Ishkanian, Adrian S

AU - Sykes, Jenna

AU - Fraser, Michael

AU - Ross-Adams, Helen

AU - Erho, Nicholas

AU - Dunning, Mark J

AU - Halim, Silvia

AU - Lamb, Alastair D

AU - Moon, Nathalie C

AU - Zafarana, Gaetano

AU - Warren, Anne Y

AU - Meng, Xianyue

AU - Thoms, John

AU - Grzadkowski, Michal R

AU - Berlin, Alejandro

AU - Have, Cherry L

AU - Ramnarine, Varune R

AU - Yao, Cindy Q

AU - Malloff, Chad A

AU - Cooper, Colin

N1 - Published under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)

PY - 2014/12

Y1 - 2014/12

N2 - Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.

AB - Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.

U2 - 10.1016/S1470-2045(14)71021-6

DO - 10.1016/S1470-2045(14)71021-6

M3 - Article

VL - 15

SP - 1521

EP - 1532

JO - The Lancet Oncology

JF - The Lancet Oncology

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