Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study

Emilie Lalonde; Adrian S. Ishkanian; Jenna Sykes; Michael Fraser; Helen Ross-Adams; Nicholas Erho; Mark J. Dunning; Silvia Halim; Alastair D. Lamb; Nathalie C. Moon; Gaetano Zafarana; Anne Y. Warren; Xianyue Meng; John  Thoms; Michal R. Grzadkowski; Alejandro Berlin; Cherry L. Have; Varune R. Ramnarine; Cindy Q. Yao; Chad A. Malloff; Lucia L. Lam; Honglei Xie; Nicholas J. Harding; Denise Y. F. Mak; Kenneth C. Chu; Lauren C. Chong; Dorota H. Sendorek; Christine P'ng; Colin C. Collins; Jeremy A. Squire; Igor Jurisica; Colin Cooper; Rosalind Eeles; Melania Pintilie; Alan Dal Pra; Elai Davicioni; Wan L. Lam; Michael Milosevic; David E. Neal; Theodorus van der Kwast; Paul C. Boutros; Robert G. Bristow

doi:10.1016/S1470-2045(14)71021-6

Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study

Emilie Lalonde, Adrian S. Ishkanian, Jenna Sykes, Michael Fraser, Helen Ross-Adams, Nicholas Erho, Mark J. Dunning, Silvia Halim, Alastair D. Lamb, Nathalie C. Moon, Gaetano Zafarana, Anne Y. Warren, Xianyue Meng, John Thoms, Michal R. Grzadkowski, Alejandro Berlin, Cherry L. Have, Varune R. Ramnarine, Cindy Q. Yao, Chad A. MalloffLucia L. Lam, Honglei Xie, Nicholas J. Harding, Denise Y. F. Mak, Kenneth C. Chu, Lauren C. Chong, Dorota H. Sendorek, Christine P'ng, Colin C. Collins, Jeremy A. Squire, Igor Jurisica, Colin Cooper, Rosalind Eeles, Melania Pintilie, Alan Dal Pra, Elai Davicioni, Wan L. Lam, Michael Milosevic, David E. Neal, Theodorus van der Kwast, Paul C. Boutros, Robert G. Bristow

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Abstract

Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.

Original language	English
Pages (from-to)	1521–1532
Number of pages	12
Journal	The Lancet Oncology
Volume	15
Issue number	13
Early online date	13 Nov 2014
DOIs	https://doi.org/10.1016/S1470-2045(14)71021-6
Publication status	Published - Dec 2014

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Lalonde, E., Ishkanian, A. S., Sykes, J., Fraser, M., Ross-Adams, H., Erho, N., Dunning, M. J., Halim, S., Lamb, A. D., Moon, N. C., Zafarana, G., Warren, A. Y., Meng, X., Thoms, J., Grzadkowski, M. R., Berlin, A., Have, C. L., Ramnarine, V. R., Yao, C. Q., ... Bristow, R. G. (2014). Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study. The Lancet Oncology, 15(13), 1521–1532. https://doi.org/10.1016/S1470-2045(14)71021-6

Lalonde, Emilie ; Ishkanian, Adrian S. ; Sykes, Jenna ; Fraser, Michael ; Ross-Adams, Helen ; Erho, Nicholas ; Dunning, Mark J. ; Halim, Silvia ; Lamb, Alastair D. ; Moon, Nathalie C. ; Zafarana, Gaetano ; Warren, Anne Y. ; Meng, Xianyue ; Thoms, John ; Grzadkowski, Michal R. ; Berlin, Alejandro ; Have, Cherry L. ; Ramnarine, Varune R. ; Yao, Cindy Q. ; Malloff, Chad A. ; Lam, Lucia L. ; Xie, Honglei ; Harding, Nicholas J. ; Mak, Denise Y. F. ; Chu, Kenneth C. ; Chong, Lauren C. ; Sendorek, Dorota H. ; P'ng, Christine ; Collins, Colin C. ; Squire, Jeremy A. ; Jurisica, Igor ; Cooper, Colin ; Eeles, Rosalind ; Pintilie, Melania ; Dal Pra, Alan ; Davicioni, Elai ; Lam, Wan L. ; Milosevic, Michael ; Neal, David E. ; van der Kwast, Theodorus ; Boutros, Paul C. ; Bristow, Robert G. / Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study. In: The Lancet Oncology. 2014 ; Vol. 15, No. 13. pp. 1521–1532.

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title = "Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study",

abstract = "Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.",

author = "Emilie Lalonde and Ishkanian, {Adrian S.} and Jenna Sykes and Michael Fraser and Helen Ross-Adams and Nicholas Erho and Dunning, {Mark J.} and Silvia Halim and Lamb, {Alastair D.} and Moon, {Nathalie C.} and Gaetano Zafarana and Warren, {Anne Y.} and Xianyue Meng and John Thoms and Grzadkowski, {Michal R.} and Alejandro Berlin and Have, {Cherry L.} and Ramnarine, {Varune R.} and Yao, {Cindy Q.} and Malloff, {Chad A.} and Lam, {Lucia L.} and Honglei Xie and Harding, {Nicholas J.} and Mak, {Denise Y. F.} and Chu, {Kenneth C.} and Chong, {Lauren C.} and Sendorek, {Dorota H.} and Christine P'ng and Collins, {Colin C.} and Squire, {Jeremy A.} and Igor Jurisica and Colin Cooper and Rosalind Eeles and Melania Pintilie and {Dal Pra}, Alan and Elai Davicioni and Lam, {Wan L.} and Michael Milosevic and Neal, {David E.} and {van der Kwast}, Theodorus and Boutros, {Paul C.} and Bristow, {Robert G.}",

note = "Published under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)",

year = "2014",

month = dec,

doi = "10.1016/S1470-2045(14)71021-6",

language = "English",

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Lalonde, E, Ishkanian, AS, Sykes, J, Fraser, M, Ross-Adams, H, Erho, N, Dunning, MJ, Halim, S, Lamb, AD, Moon, NC, Zafarana, G, Warren, AY, Meng, X, Thoms, J, Grzadkowski, MR, Berlin, A, Have, CL, Ramnarine, VR, Yao, CQ, Malloff, CA, Lam, LL, Xie, H, Harding, NJ, Mak, DYF, Chu, KC, Chong, LC, Sendorek, DH, P'ng, C, Collins, CC, Squire, JA, Jurisica, I, Cooper, C, Eeles, R, Pintilie, M, Dal Pra, A, Davicioni, E, Lam, WL, Milosevic, M, Neal, DE, van der Kwast, T, Boutros, PC & Bristow, RG 2014, 'Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study', The Lancet Oncology, vol. 15, no. 13, pp. 1521–1532. https://doi.org/10.1016/S1470-2045(14)71021-6

Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study. / Lalonde, Emilie; Ishkanian, Adrian S.; Sykes, Jenna; Fraser, Michael; Ross-Adams, Helen; Erho, Nicholas; Dunning, Mark J.; Halim, Silvia; Lamb, Alastair D.; Moon, Nathalie C.; Zafarana, Gaetano; Warren, Anne Y.; Meng, Xianyue; Thoms, John ; Grzadkowski, Michal R.; Berlin, Alejandro; Have, Cherry L.; Ramnarine, Varune R.; Yao, Cindy Q.; Malloff, Chad A.; Lam, Lucia L.; Xie, Honglei; Harding, Nicholas J.; Mak, Denise Y. F.; Chu, Kenneth C.; Chong, Lauren C.; Sendorek, Dorota H.; P'ng, Christine; Collins, Colin C.; Squire, Jeremy A.; Jurisica, Igor; Cooper, Colin; Eeles, Rosalind; Pintilie, Melania; Dal Pra, Alan; Davicioni, Elai; Lam, Wan L.; Milosevic, Michael; Neal, David E.; van der Kwast, Theodorus; Boutros, Paul C.; Bristow, Robert G.

In: The Lancet Oncology, Vol. 15, No. 13, 12.2014, p. 1521–1532.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study

AU - Lalonde, Emilie

AU - Ishkanian, Adrian S.

AU - Sykes, Jenna

AU - Fraser, Michael

AU - Ross-Adams, Helen

AU - Erho, Nicholas

AU - Dunning, Mark J.

AU - Halim, Silvia

AU - Lamb, Alastair D.

AU - Moon, Nathalie C.

AU - Zafarana, Gaetano

AU - Warren, Anne Y.

AU - Meng, Xianyue

AU - Thoms, John

AU - Grzadkowski, Michal R.

AU - Berlin, Alejandro

AU - Have, Cherry L.

AU - Ramnarine, Varune R.

AU - Yao, Cindy Q.

AU - Malloff, Chad A.

AU - Lam, Lucia L.

AU - Xie, Honglei

AU - Harding, Nicholas J.

AU - Mak, Denise Y. F.

AU - Chu, Kenneth C.

AU - Chong, Lauren C.

AU - Sendorek, Dorota H.

AU - P'ng, Christine

AU - Collins, Colin C.

AU - Squire, Jeremy A.

AU - Jurisica, Igor

AU - Cooper, Colin

AU - Eeles, Rosalind

AU - Pintilie, Melania

AU - Dal Pra, Alan

AU - Davicioni, Elai

AU - Lam, Wan L.

AU - Milosevic, Michael

AU - Neal, David E.

AU - van der Kwast, Theodorus

AU - Boutros, Paul C.

AU - Bristow, Robert G.

N1 - Published under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)

PY - 2014/12

Y1 - 2014/12

N2 - Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.

AB - Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors.

U2 - 10.1016/S1470-2045(14)71021-6

DO - 10.1016/S1470-2045(14)71021-6

M3 - Article

VL - 15

SP - 1521

EP - 1532

JO - The Lancet Oncology

JF - The Lancet Oncology

SN - 1470-2045

IS - 13

ER -