TY - JOUR
T1 - Tumour progression or pseudoprogression?
T2 - A review of post-treatment radiological appearances of glioblastoma
AU - Abdulla, S
AU - Saada, J
AU - Johnson, G
AU - Jefferies, S
AU - Ajithkumar, T
N1 - Copyright © 2015 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - Glioblastoma (GBM) is a common brain tumour in adults, which, despite multimodality treatment, has a poor median survival. Efficacy of therapy is assessed by clinical examination and magnetic resonance imaging (MRI) features. There is now a recognised subset of treated patients with imaging features that indicate "progressive disease" according to Macdonald's criteria, but subsequently, show stabilisation or resolution without a change in treatment. In these cases of "pseudoprogression", it is believed that non-tumoural causes lead to increased contrast enhancement and conventional MRI is inadequate in distinguishing this from true tumour progression. Incorrect diagnosis is important, as failure to identify pseudoprogression could lead to an inappropriate change of effective therapy. The purpose of this review is to outline the current research into radiological assessment with MRI and molecular imaging of post-treatment GBMs, specifically the differentiation between pseudoprogression and tumour progression.
AB - Glioblastoma (GBM) is a common brain tumour in adults, which, despite multimodality treatment, has a poor median survival. Efficacy of therapy is assessed by clinical examination and magnetic resonance imaging (MRI) features. There is now a recognised subset of treated patients with imaging features that indicate "progressive disease" according to Macdonald's criteria, but subsequently, show stabilisation or resolution without a change in treatment. In these cases of "pseudoprogression", it is believed that non-tumoural causes lead to increased contrast enhancement and conventional MRI is inadequate in distinguishing this from true tumour progression. Incorrect diagnosis is important, as failure to identify pseudoprogression could lead to an inappropriate change of effective therapy. The purpose of this review is to outline the current research into radiological assessment with MRI and molecular imaging of post-treatment GBMs, specifically the differentiation between pseudoprogression and tumour progression.
U2 - 10.1016/j.crad.2015.06.096
DO - 10.1016/j.crad.2015.06.096
M3 - Article
C2 - 26272530
SN - 0009-9260
VL - 70
SP - 1299
EP - 1312
JO - Clinical Radiology
JF - Clinical Radiology
IS - 11
ER -