Tumour progression or pseudoprogression? A review of post-treatment radiological appearances of glioblastoma

S Abdulla, J Saada, G Johnson, S Jefferies, T Ajithkumar

Research output: Contribution to journalArticle

33 Citations (Scopus)
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Abstract

Glioblastoma (GBM) is a common brain tumour in adults, which, despite multimodality treatment, has a poor median survival. Efficacy of therapy is assessed by clinical examination and magnetic resonance imaging (MRI) features. There is now a recognised subset of treated patients with imaging features that indicate "progressive disease" according to Macdonald's criteria, but subsequently, show stabilisation or resolution without a change in treatment. In these cases of "pseudoprogression", it is believed that non-tumoural causes lead to increased contrast enhancement and conventional MRI is inadequate in distinguishing this from true tumour progression. Incorrect diagnosis is important, as failure to identify pseudoprogression could lead to an inappropriate change of effective therapy. The purpose of this review is to outline the current research into radiological assessment with MRI and molecular imaging of post-treatment GBMs, specifically the differentiation between pseudoprogression and tumour progression.

Original languageEnglish
Pages (from-to)1299-1312
Number of pages14
JournalClinical Radiology
Volume70
Issue number11
Early online date10 Aug 2015
DOIs
Publication statusPublished - Nov 2015

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