Tuning the spontaneous formation kinetics of caffeine:malonic acid co-crystals

Karol Nartowski; Yaroslav Khimyak; David Berry

doi:10.1039/C6CE00353B

Tuning the spontaneous formation kinetics of caffeine:malonic acid co-crystals

Karol Nartowski, Yaroslav Khimyak, David Berry

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Abstract

It has previously been reported that the caffeine : malonic acid co-crystal system forms spontaneously upon the contact of the two materials. Here we studied the crystal growth in this system to rationally define the role that water plays, thus enabling us to monitor the conversion by solid-state NMR and control the kinetics of spontaneous co-crystal production by increasing or decreasing the relative humidity.

Original language	English
Pages (from-to)	2617-2620
Number of pages	4
Journal	CrystEngComm
Volume	18
Issue number	15
Early online date	15 Mar 2016
DOIs	https://doi.org/10.1039/C6CE00353B
Publication status	Published - 21 Apr 2016

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10.1039/C6CE00353BLicence: CC BY

Caffeine_cocrystal_formation_final_manuscriptAccepted author manuscript, 863 KB

Yaroslav Khimyak
- Y.Khimyakuea.acuk
- School of Chemistry, Pharmacy and Pharmacology - Professor in Solid-state NMR
- Pharmaceutical Materials and Soft Matter - Member
Person: Research Group Member, Academic, Teaching & Research

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title = "Tuning the spontaneous formation kinetics of caffeine:malonic acid co-crystals",

abstract = "It has previously been reported that the caffeine : malonic acid co-crystal system forms spontaneously upon the contact of the two materials. Here we studied the crystal growth in this system to rationally define the role that water plays, thus enabling us to monitor the conversion by solid-state NMR and control the kinetics of spontaneous co-crystal production by increasing or decreasing the relative humidity.",

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AU - Berry, David

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N2 - It has previously been reported that the caffeine : malonic acid co-crystal system forms spontaneously upon the contact of the two materials. Here we studied the crystal growth in this system to rationally define the role that water plays, thus enabling us to monitor the conversion by solid-state NMR and control the kinetics of spontaneous co-crystal production by increasing or decreasing the relative humidity.

AB - It has previously been reported that the caffeine : malonic acid co-crystal system forms spontaneously upon the contact of the two materials. Here we studied the crystal growth in this system to rationally define the role that water plays, thus enabling us to monitor the conversion by solid-state NMR and control the kinetics of spontaneous co-crystal production by increasing or decreasing the relative humidity.

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DO - 10.1039/C6CE00353B

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SN - 1466-8033

IS - 15

ER -

Tuning the spontaneous formation kinetics of caffeine:malonic acid co-crystals

Abstract

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Yaroslav Khimyak

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