TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

Anna Baumgarten; Claudia Bang; Anika Tschirner; Anke Engelmann; Volker Adams; Stephan von Haehling; Wolfram Doehner; Reinhard Pregla; Markus S Anker; Kinga Blecharz; Rudolf Meyer; Roland Hetzer; Stefan D Anker; Thomas Thum; Jochen Springer

doi:10.1016/j.ijcard.2012.12.094

TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

Anna Baumgarten, Claudia Bang, Anika Tschirner, Anke Engelmann, Volker Adams, Stephan von Haehling, Wolfram Doehner, Reinhard Pregla, Markus S Anker, Kinga Blecharz, Rudolf Meyer, Roland Hetzer, Stefan D Anker, Thomas Thum, Jochen Springer

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.

Original language	English
Pages (from-to)	1447-52
Number of pages	6
Journal	International Journal of Cardiology
Volume	168
Issue number	2
DOIs	https://doi.org/10.1016/j.ijcard.2012.12.094
Publication status	Published - 30 Sep 2013

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10.1016/j.ijcard.2012.12.094

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Baumgarten, A., Bang, C., Tschirner, A., Engelmann, A., Adams, V., von Haehling, S., Doehner, W., Pregla, R., Anker, M. S., Blecharz, K., Meyer, R., Hetzer, R., Anker, S. D., Thum, T., & Springer, J. (2013). TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy. International Journal of Cardiology, 168(2), 1447-52. https://doi.org/10.1016/j.ijcard.2012.12.094

Baumgarten, Anna ; Bang, Claudia ; Tschirner, Anika ; Engelmann, Anke ; Adams, Volker ; von Haehling, Stephan ; Doehner, Wolfram ; Pregla, Reinhard ; Anker, Markus S ; Blecharz, Kinga ; Meyer, Rudolf ; Hetzer, Roland ; Anker, Stefan D ; Thum, Thomas ; Springer, Jochen. / TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy. In: International Journal of Cardiology. 2013 ; Vol. 168, No. 2. pp. 1447-52.

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title = "TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy",

abstract = "The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.",

author = "Anna Baumgarten and Claudia Bang and Anika Tschirner and Anke Engelmann and Volker Adams and {von Haehling}, Stephan and Wolfram Doehner and Reinhard Pregla and Anker, {Markus S} and Kinga Blecharz and Rudolf Meyer and Roland Hetzer and Anker, {Stefan D} and Thomas Thum and Jochen Springer",

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year = "2013",

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day = "30",

doi = "10.1016/j.ijcard.2012.12.094",

language = "English",

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Baumgarten, A, Bang, C, Tschirner, A, Engelmann, A, Adams, V, von Haehling, S, Doehner, W, Pregla, R, Anker, MS, Blecharz, K, Meyer, R, Hetzer, R, Anker, SD, Thum, T & Springer, J 2013, 'TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy', International Journal of Cardiology, vol. 168, no. 2, pp. 1447-52. https://doi.org/10.1016/j.ijcard.2012.12.094

TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy. / Baumgarten, Anna; Bang, Claudia; Tschirner, Anika; Engelmann, Anke; Adams, Volker; von Haehling, Stephan; Doehner, Wolfram; Pregla, Reinhard; Anker, Markus S; Blecharz, Kinga; Meyer, Rudolf; Hetzer, Roland; Anker, Stefan D; Thum, Thomas; Springer, Jochen.

In: International Journal of Cardiology, Vol. 168, No. 2, 30.09.2013, p. 1447-52.

Research output: Contribution to journal › Article › peer-review

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