TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

Anna Baumgarten, Claudia Bang, Anika Tschirner, Anke Engelmann, Volker Adams, Stephan von Haehling, Wolfram Doehner, Reinhard Pregla, Markus S Anker, Kinga Blecharz, Rudolf Meyer, Roland Hetzer, Stefan D Anker, Thomas Thum, Jochen Springer

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Abstract

The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.
Original languageEnglish
Pages (from-to)1447-52
Number of pages6
JournalInternational Journal of Cardiology
Volume168
Issue number2
DOIs
Publication statusPublished - 30 Sep 2013

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