TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

Anna Baumgarten; Claudia Bang; Anika Tschirner; Anke Engelmann; Volker Adams; Stephan von Haehling; Wolfram Doehner; Reinhard Pregla; Markus S Anker; Kinga Blecharz; Rudolf Meyer; Roland Hetzer; Stefan D Anker; Thomas Thum; Jochen Springer

doi:10.1016/j.ijcard.2012.12.094

TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

Anna Baumgarten, Claudia Bang, Anika Tschirner, Anke Engelmann, Volker Adams, Stephan von Haehling, Wolfram Doehner, Reinhard Pregla, Markus S Anker, Kinga Blecharz, Rudolf Meyer, Roland Hetzer, Stefan D Anker, Thomas Thum, Jochen Springer

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.

Original language	English
Pages (from-to)	1447-52
Number of pages	6
Journal	International Journal of Cardiology
Volume	168
Issue number	2
DOIs	https://doi.org/10.1016/j.ijcard.2012.12.094
Publication status	Published - 30 Sept 2013

Access to Document

10.1016/j.ijcard.2012.12.094

Cite this

Baumgarten, A., Bang, C., Tschirner, A., Engelmann, A., Adams, V., von Haehling, S., Doehner, W., Pregla, R., Anker, M. S., Blecharz, K., Meyer, R., Hetzer, R., Anker, S. D., Thum, T., & Springer, J. (2013). TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy. International Journal of Cardiology, 168(2), 1447-52. https://doi.org/10.1016/j.ijcard.2012.12.094

@article{0a215b310c32411a8f4990029e6efb4b,

title = "TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy",

abstract = "The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.",

author = "Anna Baumgarten and Claudia Bang and Anika Tschirner and Anke Engelmann and Volker Adams and {von Haehling}, Stephan and Wolfram Doehner and Reinhard Pregla and Anker, {Markus S} and Kinga Blecharz and Rudolf Meyer and Roland Hetzer and Anker, {Stefan D} and Thomas Thum and Jochen Springer",

note = "Copyright {\textcopyright} 2013. Published by Elsevier Ireland Ltd.",

year = "2013",

month = sep,

day = "30",

doi = "10.1016/j.ijcard.2012.12.094",

language = "English",

volume = "168",

pages = "1447--52",

journal = "International Journal of Cardiology",

issn = "1874-1754",

publisher = "Elsevier",

number = "2",

}

Baumgarten, A, Bang, C, Tschirner, A, Engelmann, A, Adams, V, von Haehling, S, Doehner, W, Pregla, R, Anker, MS, Blecharz, K, Meyer, R, Hetzer, R, Anker, SD, Thum, T & Springer, J 2013, 'TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy', International Journal of Cardiology, vol. 168, no. 2, pp. 1447-52. https://doi.org/10.1016/j.ijcard.2012.12.094

TY - JOUR

T1 - TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

AU - Baumgarten, Anna

AU - Bang, Claudia

AU - Tschirner, Anika

AU - Engelmann, Anke

AU - Adams, Volker

AU - von Haehling, Stephan

AU - Doehner, Wolfram

AU - Pregla, Reinhard

AU - Anker, Markus S

AU - Blecharz, Kinga

AU - Meyer, Rudolf

AU - Hetzer, Roland

AU - Anker, Stefan D

AU - Thum, Thomas

AU - Springer, Jochen

PY - 2013/9/30

Y1 - 2013/9/30

N2 - The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.

AB - The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.

U2 - 10.1016/j.ijcard.2012.12.094

DO - 10.1016/j.ijcard.2012.12.094

M3 - Article

C2 - 23360823

SN - 1874-1754

VL - 168

SP - 1447

EP - 1452

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 2

ER -