Two-hit wonders: The expanding universe of multitargeting epigenetic agents

Angel R. De Lera; A. Ganesan

doi:10.1016/j.cbpa.2020.05.009

Two-hit wonders: The expanding universe of multitargeting epigenetic agents

Angel R. De Lera, A. Ganesan

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Multitargeting involves the application of molecules that are deliberately intended to bind to two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and drug discovery, the rational design of multitargeting agents has evolved to a sophisticated level, and there are now five examples that have reached clinical trials. This review covers recent developments in the field and future prospects.

Original language	English
Pages (from-to)	135-154
Number of pages	20
Journal	Current Opinion in Chemical Biology
Volume	57
Early online date	9 Aug 2020
DOIs	https://doi.org/10.1016/j.cbpa.2020.05.009
Publication status	Published - Aug 2020

Keywords

Chemical probes
Drug discovery
Epigenetics
Multitargeting agents

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10.1016/j.cbpa.2020.05.009

https://linkinghub.elsevier.com/retrieve/pii/S1367593120300806

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abstract = "Multitargeting involves the application of molecules that are deliberately intended to bind to two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and drug discovery, the rational design of multitargeting agents has evolved to a sophisticated level, and there are now five examples that have reached clinical trials. This review covers recent developments in the field and future prospects.",

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AB - Multitargeting involves the application of molecules that are deliberately intended to bind to two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and drug discovery, the rational design of multitargeting agents has evolved to a sophisticated level, and there are now five examples that have reached clinical trials. This review covers recent developments in the field and future prospects.

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JF - Current Opinion in Chemical Biology

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Two-hit wonders: The expanding universe of multitargeting epigenetic agents

Abstract

Keywords

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A. Ganesan

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