Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants

Jack R. Peart, Rui Lu, Ari Sadanandom, Isabelle Malcuit, Peter Moffett, David C. Brice, Leif Schauser, Daniel A. W. Jaggard, Shunyuan Xiao, Mark J. Coleman, Max Dow, Jonathan D. G. Jones, Ken Shirasu, David C. Baulcombe

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331 Citations (Scopus)

Abstract

Homologues of the yeast ubiquitin ligase-associated protein SGT1 are required for disease resistance in plants mediated by nucleotide-binding site/leucine-rich repeat (NBS-LRR) proteins. Here, by silencing SGT1 in Nicotiana benthamiana, we extend these findings and demonstrate that SGT1 has an unexpectedly general role in disease resistance. It is required for resistance responses mediated by NBS-LRR and other R proteins in which pathogen-derived elicitors are recognized either inside or outside the host plant cell. A requirement also exists for SGT1 in nonhost resistance in which all known members of a host species are resistant against every characterized isolate of a pathogen. Our findings show that silencing SGT1 affects diverse types of disease resistance in plants and support the idea that R protein-mediated and nonhost resistance may involve similar mechanisms.
Original languageEnglish
Pages (from-to)10865-10869
Number of pages5
JournalProceedings of the National Academy of Sciences USA
Volume99
Issue number16
DOIs
Publication statusPublished - 6 Aug 2002

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