UK clinicians’ attitudes towards the application of molecular diagnostics to guide antibiotic use in ICU patients with pneumonias: A quantitative study

Sarah-Jane F. Stewart, Alyssa M. Pandolfo, Zoe Moon, Yogini Jani, Stephen J. Brett, David Brealey, Suveer Singh, Virve I. Enne, David M. Livermore, Vanya Gant, Robert Horne, INHALE Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Molecular diagnostic tests may improve antibiotic prescribing by enabling earlier tailoring of antimicrobial therapy. However, clinicians’ trust and acceptance of these tests will determine their application in practice.

Objectives: To examine ICU prescribers’ views on the application of molecular diagnostics in patients with suspected hospital-acquired and ventilator-associated pneumonia (HAP/VAP).

Methods: Sixty-three ICU clinicians from five UK hospitals completed a cross-sectional questionnaire between May 2020 and July 2020 assessing attitudes towards using molecular diagnostics to inform initial agent choice and to help stop broad-spectrum antibiotics early.

Results: Attitudes towards using molecular diagnostics to inform initial treatment choices and to stop broad-spectrum antibiotics early were nuanced. Most (83%) were positive about molecular diagnostics, agreeing that using results to inform broad-spectrum antibiotic prescribing is good practice. However, many (58%) believed sick patients are often too unstable to risk stopping broad-spectrum antibiotics based on a negative result.

Conclusions: Positive attitudes towards the application of molecular diagnostics to improve antibiotic stewardship were juxtapositioned against the perceived need to initiate and maintain broad-spectrum antibiotics to protect unstable patients.
Original languageEnglish
Pages (from-to)123–127
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume79
Issue number1
Early online date16 Nov 2023
DOIs
Publication statusPublished - 3 Jan 2024

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