UK epidemic Escherichia coli strains A-E, with CTX-M-15 β-lactamase, all belong to the international O25:H4-ST131 clone

Siu Ha Lau, Mary E. Kaufmann, David M. Livermore, Neil Woodford, Geraldine A Willshaw, Tom Cheasty, Katie Stamper, Suganya Reddy, John Cheesbrough, Frederick J. Bolton, Andrew J. Fox, Mathew Upton

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Objectives Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum ß-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A–E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli. Methods Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK. Results Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage. Conclusions The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.
Original languageEnglish
Pages (from-to)1241-1244
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Issue number6
Publication statusPublished - Dec 2008


  • Bacterial Typing Techniques
  • Cluster Analysis
  • DNA Fingerprinting
  • Electrophoresis, Gel, Pulsed-Field
  • Escherichia coli
  • Escherichia coli Infections
  • Genotype
  • Great Britain
  • Humans
  • Molecular Epidemiology
  • Sequence Analysis, DNA
  • Serotyping
  • beta-Lactamases

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