Ultrathin selective molecularly imprinted polymer microdots obtained by evanescent wave photopolymerization

Yannick Fuchs; Ana V. Linares; Andrew G. Mayes; Karsten Haupt; Olivier Soppera

doi:10.1021/cm2009829

Ultrathin selective molecularly imprinted polymer microdots obtained by evanescent wave photopolymerization

Yannick Fuchs, Ana V. Linares, Andrew G. Mayes, Karsten Haupt, Olivier Soppera

Chemistry of Materials and Catalysis

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The fabrication of ultrathin selective molecularly imprinted polymer (MIP) microdots using polymerization by evanescent waves (PEW) is demonstrated for the first time. A specific prepolymerization mixture exhibiting suitable photosentivity at 405 nm was developed, containing in particular the visible-light photoinitiator bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide. PEW allows for nanometric resolution of the MIP dots in the z-scale. Within a few seconds, it is possible to generate molecularly imprinted microdots with sub-100 nm thickness. The amino acid Z-(l)-phenylalanine was used as model imprinting template, and the fluorescent dansyl-phenylalanine was employed as a fluorescently labeled derivative for the recognition tests. The MIP microdots showed specific molecular recognition for (l)-phenylalanine derivatives and were able to discriminate dansyl-(l)-phenylalanine from dansyl-(d)-phenylalanine.

Original language	English
Pages (from-to)	3645-3651
Number of pages	7
Journal	Chemistry of Materials
Volume	23
Issue number	16
DOIs	https://doi.org/10.1021/cm2009829
Publication status	Published - 29 Jul 2011

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10.1021/cm2009829

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title = "Ultrathin selective molecularly imprinted polymer microdots obtained by evanescent wave photopolymerization",

abstract = "The fabrication of ultrathin selective molecularly imprinted polymer (MIP) microdots using polymerization by evanescent waves (PEW) is demonstrated for the first time. A specific prepolymerization mixture exhibiting suitable photosentivity at 405 nm was developed, containing in particular the visible-light photoinitiator bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide. PEW allows for nanometric resolution of the MIP dots in the z-scale. Within a few seconds, it is possible to generate molecularly imprinted microdots with sub-100 nm thickness. The amino acid Z-(l)-phenylalanine was used as model imprinting template, and the fluorescent dansyl-phenylalanine was employed as a fluorescently labeled derivative for the recognition tests. The MIP microdots showed specific molecular recognition for (l)-phenylalanine derivatives and were able to discriminate dansyl-(l)-phenylalanine from dansyl-(d)-phenylalanine.",

author = "Yannick Fuchs and Linares, {Ana V.} and Mayes, {Andrew G.} and Karsten Haupt and Olivier Soppera",

year = "2011",

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T1 - Ultrathin selective molecularly imprinted polymer microdots obtained by evanescent wave photopolymerization

AU - Fuchs, Yannick

AU - Linares, Ana V.

AU - Mayes, Andrew G.

AU - Haupt, Karsten

AU - Soppera, Olivier

PY - 2011/7/29

Y1 - 2011/7/29

N2 - The fabrication of ultrathin selective molecularly imprinted polymer (MIP) microdots using polymerization by evanescent waves (PEW) is demonstrated for the first time. A specific prepolymerization mixture exhibiting suitable photosentivity at 405 nm was developed, containing in particular the visible-light photoinitiator bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide. PEW allows for nanometric resolution of the MIP dots in the z-scale. Within a few seconds, it is possible to generate molecularly imprinted microdots with sub-100 nm thickness. The amino acid Z-(l)-phenylalanine was used as model imprinting template, and the fluorescent dansyl-phenylalanine was employed as a fluorescently labeled derivative for the recognition tests. The MIP microdots showed specific molecular recognition for (l)-phenylalanine derivatives and were able to discriminate dansyl-(l)-phenylalanine from dansyl-(d)-phenylalanine.

AB - The fabrication of ultrathin selective molecularly imprinted polymer (MIP) microdots using polymerization by evanescent waves (PEW) is demonstrated for the first time. A specific prepolymerization mixture exhibiting suitable photosentivity at 405 nm was developed, containing in particular the visible-light photoinitiator bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide. PEW allows for nanometric resolution of the MIP dots in the z-scale. Within a few seconds, it is possible to generate molecularly imprinted microdots with sub-100 nm thickness. The amino acid Z-(l)-phenylalanine was used as model imprinting template, and the fluorescent dansyl-phenylalanine was employed as a fluorescently labeled derivative for the recognition tests. The MIP microdots showed specific molecular recognition for (l)-phenylalanine derivatives and were able to discriminate dansyl-(l)-phenylalanine from dansyl-(d)-phenylalanine.

U2 - 10.1021/cm2009829

DO - 10.1021/cm2009829

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