@article{7fd032740ae24482829409f24f0dfbe6,
title = "Unguiculins A-C: Cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp",
abstract = "Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2{\textendash}3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range.",
keywords = "Crambeidae, guanidine, Monanchora, spermidine alkaloid, unguiculin",
author = "Amr El-Demerdash and C{\'e}line Moriou and Martin, \{Marie Th{\'e}r{\`e}se\} and Sylvain Petek and C{\'e}cile Debitus and Ali Al-Mourabit",
note = "Funding Information: This work was supported by the mission sector of the Ministry of High Educationof the Arab Republic of Egypt (Egyptian Cultural Bureau in Paris), where Amr El-Demerdash{\textquoteright}s Ph.D. was granted and completely funded. Financial support from CNRS-ICSN and IRD for the collection trip aboard R/V Alis. The French and French Polynesian governments for the Marquesas project, and ANR POMARE project, 2011-EBIM-006-01, are gratefully acknowledged. We thank F. Pelissier and O. Thoison for HPLC assistance. Special thanks for J.F. Gallard and K. Hammad for technical assistance and NMR measurements. We thank T. Cresteil and G. Aubert for cytotoxicity evaluations. Funding Information: This work was supported by the mission sector of the Ministry of High Educationof the Arab Republic of Egypt (Egyptian Cultural Bureau in Paris), where Amr El-Demerdash{\textquoteright}s Ph.D. was granted and completely funded. Financial support from CNRS-ICSN and IRD for the collection trip aboard R/V Alis. The French and French Polynesian governments for the Marquesas project, and ANR POMARE project, 2011-EBIM-006-01, are gratefully acknowledged. Publisher Copyright: {\textcopyright} 2017 Informa UK Limited, trading as Taylor \& Francis Group.",
year = "2018",
month = jul,
day = "3",
doi = "10.1080/14786419.2017.1385011",
language = "English",
volume = "32",
pages = "1512--1517",
journal = "Natural Product Research",
issn = "1478-6419",
publisher = "Taylor and Francis",
number = "13",
}
SDG 3 Good Health and Well-being