Unlocking the genome of the human typhoid bacillus

John Wain, Deborah House, Julian Parkhill, Christopher Parry, Gordon Dougan

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Molecular studies are shedding new light on the pathogenesis of human typhoid fever, which is still a very common disease in developing countries. For example, the total genome DNA sequence has recently been determined for a multiple-drug-resistant Salmonella typhi, the serotype that is the cause of typhoid fever. The genome sequence showed many distinguishing features, including clusters of S typhi specific genes and a large number--over 200--of pseudogenes. This information, together with other molecular studies, has provided vital clues in several important areas of typhoid biology. We have new insights into the mechanisms underpinning the human host specificity of S typhi, and have exploitable new routes to improved diagnostics and a better understanding of the epidemiology of the disease.
Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalThe Lancet Infectious Diseases
Issue number3
Publication statusPublished - Mar 2002

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