Unravelling mechanistic insights in the platinum-catalysed dihydroalkoxylation of allenes

Maria Quiros Lopez, Enrique Gomez-Bengoa, Maria Paz Munoz-Herranz

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Abstract

The mechanism of the platinum-catalysed dihydroalkoxylation of allenes to give acetals has been studied experimentally and by computational methods. Our findings further explain divergent reactivity encountered for platinum- and gold-vinyl intermediates after the first nucleophilic attack onto the coordinated allene, as well as provide new details on the catalytic cycle with platinum, uncovering enol ethers as resting states of the catalytic cycle, a S(E)Ox process via Pt(V)-H as the final protodemetallation step after the second nucleophilic attack when neutral platinum complexes are used, and a fast acid promoted addition of methanol to enol ethers when cationic platinum complexes are employed.

Original languageEnglish
Pages (from-to)167-177
Number of pages11
JournalPure and Applied Chemistry
Volume92
Issue number1
Early online date16 Dec 2019
DOIs
Publication statusPublished - 28 Jan 2020

Keywords

  • ACTIVATION
  • ALLYLIC ETHERS
  • CHEMISTRY
  • COMPLEXES
  • DYNAMIC SOLUTION BEHAVIOR
  • GOLD CATALYSIS
  • GOLD(I)-CATALYZED INTERMOLECULAR HYDROALKOXYLATION
  • HYDROAMINATION
  • ICPOC-24
  • PROTONOLYSIS
  • PT-C BOND
  • allenes
  • catalysis
  • gold
  • hydroalkoxylation
  • mechanism
  • platinum

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