Urinary excretion of pyridinium crosslinks in healthy 4-10 year olds

Shahid M. Husain, Zulf Mughal, Gwen Williams, Kate Ward, Colin S. Smith, John Dutton, William D. Fraser

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25 Citations (Scopus)


Urinary pyridinoline and deoxypyridinoline, pyridinium crosslinks released during breakdown of mature collagen, might serve as useful markers of bone resorption. Before their role can be identified, reference values must be established. In this study, free pyridinoline (f-Pyr), free deoxypyridinoline (f-DPyr), and creatinine (Cr) were measured in first morning void urine samples from 250 girls and 265 boys between the ages of 4 and 10 years. Overall, there was a decrease in f-Pyr:Cr and f-DPyr:Cr ratios with increasing age in both sexes, but there was a wide range of values for individuals of similar ages. Further studies are required to assess whether urinary pyridinium crosslink excretion is sufficiently deranged in conditions affecting bone metabolism for the measurement of these compounds to be of clinical value.
Original languageEnglish
Pages (from-to)370-373
Number of pages4
JournalArchives of Disease in Childhood
Issue number4
Publication statusPublished - Apr 1999


  • Age Factors
  • Amino Acids
  • Biological Markers
  • Child
  • Child, Preschool
  • Collagen
  • Creatinine
  • Female
  • Humans
  • Male
  • Reference Values
  • Sex Characteristics

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