Urinary excretion of pyridinium crosslinks in healthy 4-10 year olds

Shahid M. Husain; Zulf Mughal; Gwen Williams; Kate Ward; Colin S. Smith; John Dutton; William D. Fraser

doi:10.1136/adc.80.4.370

Urinary excretion of pyridinium crosslinks in healthy 4-10 year olds

Shahid M. Husain, Zulf Mughal, Gwen Williams, Kate Ward, Colin S. Smith, John Dutton, William D. Fraser

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Urinary pyridinoline and deoxypyridinoline, pyridinium crosslinks released during breakdown of mature collagen, might serve as useful markers of bone resorption. Before their role can be identified, reference values must be established. In this study, free pyridinoline (f-Pyr), free deoxypyridinoline (f-DPyr), and creatinine (Cr) were measured in first morning void urine samples from 250 girls and 265 boys between the ages of 4 and 10 years. Overall, there was a decrease in f-Pyr:Cr and f-DPyr:Cr ratios with increasing age in both sexes, but there was a wide range of values for individuals of similar ages. Further studies are required to assess whether urinary pyridinium crosslink excretion is sufficiently deranged in conditions affecting bone metabolism for the measurement of these compounds to be of clinical value.

Original language	English
Pages (from-to)	370-373
Number of pages	4
Journal	Archives of Disease in Childhood
Volume	80
Issue number	4
DOIs	https://doi.org/10.1136/adc.80.4.370
Publication status	Published - Apr 1999

Keywords

Age Factors
Amino Acids
Biological Markers
Child
Child, Preschool
Collagen
Creatinine
Female
Humans
Male
Reference Values
Sex Characteristics

Access to Document

10.1136/adc.80.4.370

Cite this

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title = "Urinary excretion of pyridinium crosslinks in healthy 4-10 year olds",

abstract = "Urinary pyridinoline and deoxypyridinoline, pyridinium crosslinks released during breakdown of mature collagen, might serve as useful markers of bone resorption. Before their role can be identified, reference values must be established. In this study, free pyridinoline (f-Pyr), free deoxypyridinoline (f-DPyr), and creatinine (Cr) were measured in first morning void urine samples from 250 girls and 265 boys between the ages of 4 and 10 years. Overall, there was a decrease in f-Pyr:Cr and f-DPyr:Cr ratios with increasing age in both sexes, but there was a wide range of values for individuals of similar ages. Further studies are required to assess whether urinary pyridinium crosslink excretion is sufficiently deranged in conditions affecting bone metabolism for the measurement of these compounds to be of clinical value.",

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author = "Husain, {Shahid M.} and Zulf Mughal and Gwen Williams and Kate Ward and Smith, {Colin S.} and John Dutton and Fraser, {William D.}",

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T1 - Urinary excretion of pyridinium crosslinks in healthy 4-10 year olds

AU - Husain, Shahid M.

AU - Mughal, Zulf

AU - Williams, Gwen

AU - Ward, Kate

AU - Smith, Colin S.

AU - Dutton, John

AU - Fraser, William D.

PY - 1999/4

Y1 - 1999/4

N2 - Urinary pyridinoline and deoxypyridinoline, pyridinium crosslinks released during breakdown of mature collagen, might serve as useful markers of bone resorption. Before their role can be identified, reference values must be established. In this study, free pyridinoline (f-Pyr), free deoxypyridinoline (f-DPyr), and creatinine (Cr) were measured in first morning void urine samples from 250 girls and 265 boys between the ages of 4 and 10 years. Overall, there was a decrease in f-Pyr:Cr and f-DPyr:Cr ratios with increasing age in both sexes, but there was a wide range of values for individuals of similar ages. Further studies are required to assess whether urinary pyridinium crosslink excretion is sufficiently deranged in conditions affecting bone metabolism for the measurement of these compounds to be of clinical value.

AB - Urinary pyridinoline and deoxypyridinoline, pyridinium crosslinks released during breakdown of mature collagen, might serve as useful markers of bone resorption. Before their role can be identified, reference values must be established. In this study, free pyridinoline (f-Pyr), free deoxypyridinoline (f-DPyr), and creatinine (Cr) were measured in first morning void urine samples from 250 girls and 265 boys between the ages of 4 and 10 years. Overall, there was a decrease in f-Pyr:Cr and f-DPyr:Cr ratios with increasing age in both sexes, but there was a wide range of values for individuals of similar ages. Further studies are required to assess whether urinary pyridinium crosslink excretion is sufficiently deranged in conditions affecting bone metabolism for the measurement of these compounds to be of clinical value.

KW - Age Factors

KW - Amino Acids

KW - Biological Markers

KW - Child

KW - Child, Preschool

KW - Collagen

KW - Creatinine

KW - Female

KW - Humans

KW - Male

KW - Reference Values

KW - Sex Characteristics

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