Use of the stable isotope (106)Cd for studying dietary cadmium absorption in humans

Helen M. Crews, Linda M. Owen, Nicola Langford, Susan J. Fairweather-Tait, Tom E. Fox, Lisa Hubbard, Diane Phillips

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Hydroponically grown wheat was intrinsically labelled with the stable isotope 106cadmium (106Cd) and the flour made into a porridge. The abundance of the isotope in the porridge was approximately 30 times the natural abundance, but the total level of Cd in the porridge was 0.03 mg/kg fresh weight, which was the same as expected in a normal diet. Cadmium measurements were made using inductively coupled plasma-mass spectrometry (ICP-MS). The porridge was eaten at breakfast by adult and infant volunteers. Bulked faecal collections were analysed for unabsorbed Cd. Initial results suggest that the apparent absorption of Cd may be higher than 5% as commonly quoted, but longer faecal collection times may be necessary to confirm this.
Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalToxicology Letters
Volume112-113
DOIs
Publication statusPublished - 15 Mar 2000

Keywords

  • Adult
  • Cadmium
  • Cereals
  • Diet
  • Feces
  • Female
  • Humans
  • Infant
  • Intestinal Absorption
  • Isotopes
  • Mass Spectrometry
  • Middle Aged

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