Using capsaicin modified multiwalled carbon nanotube based electrodes and p-chloranil modified carbon paste electrodes for the determination of amines: Application to benzocaine and lidocaine

Roohollah T. Kachoosangi, Gregory Wildgoose, Richard G. Compton

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


The utilization of the capsaicin modified carbon nanotube modified basal-plane pyrolytic graphite electrode or p-chloranil modified carbon paste electrodes are presented for the determination of pharmaceutical compounds containing amine functionality, such as benzocaine and lidocaine. In detection of benzocaine at a capsaicin modified electrode, the guaiacol functional group is irreversibly electrochemically oxidized to form the o-quinone derivative which then undergoes nucleophilic attack by the aromatic amine group in benzocaine via a 1,4-Michael addition mechanism forming a catechol-amine adduct. The electrochemically initiated formation of the capsaicin-benzocaine adduct causes a linear decrease in the voltammetric signal corresponding to capsaicin which correlates to the added concentration of benzocaine.
Original languageEnglish
Pages (from-to)2495-2500
Number of pages6
Issue number23
Publication statusPublished - Dec 2008

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