Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin D and prostate cancer risk

Carolina Bonilla, Rebecca Gilbert, John P Kemp, Nicholas J Timpson, David M Evans, Jenny L Donovan, Freddie C Hamdy, David E Neal, William D Fraser, George Davey Smith, Sarah J Lewis, Mark Lathrop, Richard M Martin

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18 Citations (Scopus)

Abstract

Ecological and epidemiological studies have identified an inverse association of intensity and duration of sunlight exposure with prostate cancer, which may be explained by a reduction in vitamin D synthesis. Pigmentation traits influence sun exposure and therefore may affect prostate cancer risk. Because observational studies are vulnerable to confounding and measurement error, we used Mendelian randomization to examine the relationship of sun exposure with both prostate cancer risk and the intermediate phenotype, plasma levels of vitamin D.
Original languageEnglish
Pages (from-to)597-606
Number of pages10
JournalCancer Epidemiology, Biomarkers & Prevention
Volume22
Issue number4
DOIs
Publication statusPublished - Apr 2013

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