Validation study of the Italian Addenbrooke's Cognitive Examination Revised in a young-old and old-old population

M. Pigliautile, M. Ricci, E. Mioshi, S. Ercolani, F. Mangialasche, R. Monastero, M. F. Croce, S. Federici, P. Mecocci

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AIMS: The main aims of the study were the translation and the subsequent validation in Italian of the Addenbrooke's Cognitive Examination Revised (ACE-R), and the evaluation of its usefulness in discriminating cognitively normal subjects from patients with mild dementia in an elderly population.

METHODS: The ACE-R was translated and adapted into Italian. The Italian ACE-R was administered to a group of 179 elderly subjects (72 cognitively healthy and 107 subjects with mild dementia, mean age 75.4±6.4 years). The group was stratified into two subsamples according to age, i.e. a young-old (<75 years) and an old-old (≥75 years) group, in order to evaluate the sensitivity and specificity of the test in detecting dementia in different age strata of elderly subjects.

RESULTS: The reliability of the Italian ACE-R was extremely good (α-coefficient=0.85). Two different cutoffs were identified for young-old (cutoff 79; sensitivity 90% and specificity 80%) and old-old subjects (cutoff 60; sensitivity 82% and specificity 100%).

CONCLUSIONS: The Italian ACE-R is a valid screening tool to detect dementia, especially in the old-old population, which represents not only the fastest growing age group but also the group at the highest risk of dementia in Western countries.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Issue number5
Publication statusPublished - 2011


  • Aged
  • Aged, 80 and over
  • Alzheimer Disease/diagnosis
  • Cognitive Dysfunction/diagnosis
  • Cross-Cultural Comparison
  • Dementia/diagnosis
  • Dementia, Vascular/diagnosis
  • Female
  • Frontotemporal Dementia/diagnosis
  • Humans
  • Italy
  • Lewy Body Disease/diagnosis
  • Male
  • Mental Status Schedule/statistics & numerical data
  • Neuropsychological Tests/statistics & numerical data
  • Psychometrics/statistics & numerical data
  • Reference Values
  • Reproducibility of Results
  • Translating

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