Virus factories and mini-organelles generated for virus replication

Tom Wileman, Chris Netherton, Penny Powell

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

2 Citations (Scopus)


Many viruses replicate and assemble in subcellular microenvironments called virus factories or “viroplasm”. Virus factories increase the efficiency of replication and at the same time protect viruses from antiviral defenses. We describe how viruses reorganize cellular membrane compartments and cytoskeleton to generate these “mini-organelles” and how these rearrangements parallel cellular responses to stress such as protein aggregation and DNA damage.
Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology (Second Edition)
EditorsRalph A. Bradshaw, Gerald W. Hart, Philip D. Stahl
Number of pages13
ISBN (Print)978-0-12-821624-8
Publication statusPublished - 2023


  • Aggresome
  • Autophagosome
  • Autophagy
  • Double membrane vesicle
  • PML-nb
  • Replicase
  • Spherule
  • Viroplasm
  • Virus factory
  • Virus replication

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