Virus factories and mini-organelles generated for virus replication

Tom Wileman; Chris Netherton; Penny Powell

doi:10.1016/B978-0-12-821618-7.00041-9

Virus factories and mini-organelles generated for virus replication

Tom Wileman, Chris Netherton, Penny Powell

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

3 Citations (Scopus)

Abstract

Many viruses replicate and assemble in subcellular microenvironments called virus factories or “viroplasm”. Virus factories increase the efficiency of replication and at the same time protect viruses from antiviral defenses. We describe how viruses reorganize cellular membrane compartments and cytoskeleton to generate these “mini-organelles” and how these rearrangements parallel cellular responses to stress such as protein aggregation and DNA damage.

Original language	English
Title of host publication	Encyclopedia of Cell Biology (Second Edition)
Editors	Ralph A. Bradshaw, Gerald W. Hart, Philip D. Stahl
Publisher	Elsevier
Pages	423-435
Number of pages	13
Edition	2
ISBN (Print)	978-0-12-821624-8
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00041-9
Publication status	Published - 2023

Keywords

Aggresome
Autophagosome
Autophagy
Double membrane vesicle
PML-nb
Replicase
Spherule
Viroplasm
Virus factory
Virus replication

Access to Document

10.1016/B978-0-12-821618-7.00041-9

Cite this

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title = "Virus factories and mini-organelles generated for virus replication",

abstract = "Many viruses replicate and assemble in subcellular microenvironments called virus factories or “viroplasm”. Virus factories increase the efficiency of replication and at the same time protect viruses from antiviral defenses. We describe how viruses reorganize cellular membrane compartments and cytoskeleton to generate these “mini-organelles” and how these rearrangements parallel cellular responses to stress such as protein aggregation and DNA damage.",

keywords = "Aggresome, Autophagosome, Autophagy, Double membrane vesicle, PML-nb, Replicase, Spherule, Viroplasm, Virus factory, Virus replication",

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T1 - Virus factories and mini-organelles generated for virus replication

AU - Wileman, Tom

AU - Netherton, Chris

AU - Powell, Penny

PY - 2023

Y1 - 2023

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AB - Many viruses replicate and assemble in subcellular microenvironments called virus factories or “viroplasm”. Virus factories increase the efficiency of replication and at the same time protect viruses from antiviral defenses. We describe how viruses reorganize cellular membrane compartments and cytoskeleton to generate these “mini-organelles” and how these rearrangements parallel cellular responses to stress such as protein aggregation and DNA damage.

KW - Aggresome

KW - Autophagosome

KW - Autophagy

KW - Double membrane vesicle

KW - PML-nb

KW - Replicase

KW - Spherule

KW - Viroplasm

KW - Virus factory

KW - Virus replication

U2 - 10.1016/B978-0-12-821618-7.00041-9

DO - 10.1016/B978-0-12-821618-7.00041-9

M3 - Entry for encyclopedia/dictionary

AN - SCOPUS:85042804859

SN - 978-0-12-821624-8

SP - 423

EP - 435

BT - Encyclopedia of Cell Biology (Second Edition)

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A2 - Hart, Gerald W.

A2 - Stahl, Philip D.

PB - Elsevier

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