Visual function and white matter microstructure in very-low-birth-weight (VLBW) adolescents--a DTI study

Susanne Lindqvist, Jon Skranes, Live Eikenes, Olav Haraldseth, Torstein Vik, Ann-Mari Brubakk, Torgil Riise Vangberg

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14 Citations (Scopus)

Abstract

Premature birth is associated with visual impairments, due to both cerebral and ocular pathology. This study examined the relationship between cerebral white matter microstructure, evaluated by diffusion tensor imaging (DTI), and visual function, in 30 preterm born adolescents with very low birth weight (VLBW=birth weight⩽1500g) and an age-matched group of 45 term born controls. Visual acuity correlated positively with fractional anisotropy (FA) in corpus callosum and in frontal white matter areas in the VLBW participants, but not in the control participants. Callosal visual connections may play a more important role in the development of good visual acuity than previously acknowledged in preterm born children.
Original languageEnglish
Pages (from-to)2063-70
Number of pages8
JournalVision Research
Volume51
Issue number18
DOIs
Publication statusPublished - 15 Sep 2011
Externally publishedYes

Keywords

  • Adolescent
  • Brain
  • Diffusion Tensor Imaging
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Very Low Birth Weight
  • Male
  • Regression Analysis
  • Vision, Ocular
  • Visual Acuity

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