Vitamin K status of preterm infants with a prolonged prothrombin time

Paul Clarke; Simon J. Mitchell; Shanmuga Sundaram; Vibha Sharma; Robert Wynn; Martin J. Shearer

doi:10.1080/08035250500268233

Vitamin K status of preterm infants with a prolonged prothrombin time

Paul Clarke
, Simon J. Mitchell
, Shanmuga Sundaram
, Vibha Sharma
, Robert Wynn
, Martin J. Shearer

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Aim: To investigate the vitamin K status of preterm infants who have a prolonged prothrombin time (PT) in the first month of life. Methods: Measures of vitamin K status were assessed in 21 preterm infants who were found to have an abnormal PT, despite 0.2-0.5 mg vitamin K₁ prophylaxis at birth. Results: All infants had normal or supraphysiological vitamin K₁ concentrations and undetectable or, in one infant, insignificant PIVKA-II, indicating adequate vitamin K status. Conclusion: In preterm infants born at < 32 wk gestation who received ≥ 0.2 mg vitamin K₁ after delivery, a prolonged PT in the first month of life is unlikely to be due to vitamin K deficiency.

Original language	English
Pages (from-to)	1822-1824
Number of pages	3
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	94
Issue number	12
DOIs	https://doi.org/10.1080/08035250500268233
Publication status	Published - 1 Dec 2005
Externally published	Yes

Keywords

Phylloquinone
PIVKA-II
Premature

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10.1080/08035250500268233

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title = "Vitamin K status of preterm infants with a prolonged prothrombin time",

abstract = "Aim: To investigate the vitamin K status of preterm infants who have a prolonged prothrombin time (PT) in the first month of life. Methods: Measures of vitamin K status were assessed in 21 preterm infants who were found to have an abnormal PT, despite 0.2-0.5 mg vitamin K1 prophylaxis at birth. Results: All infants had normal or supraphysiological vitamin K1 concentrations and undetectable or, in one infant, insignificant PIVKA-II, indicating adequate vitamin K status. Conclusion: In preterm infants born at < 32 wk gestation who received ≥ 0.2 mg vitamin K1 after delivery, a prolonged PT in the first month of life is unlikely to be due to vitamin K deficiency.",

keywords = "Phylloquinone, PIVKA-II, Premature",

author = "Paul Clarke and Mitchell, \{Simon J.\} and Shanmuga Sundaram and Vibha Sharma and Robert Wynn and Shearer, \{Martin J.\}",

year = "2005",

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doi = "10.1080/08035250500268233",

language = "English",

volume = "94",

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TY - JOUR

T1 - Vitamin K status of preterm infants with a prolonged prothrombin time

AU - Clarke, Paul

AU - Mitchell, Simon J.

AU - Sundaram, Shanmuga

AU - Sharma, Vibha

AU - Wynn, Robert

AU - Shearer, Martin J.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Aim: To investigate the vitamin K status of preterm infants who have a prolonged prothrombin time (PT) in the first month of life. Methods: Measures of vitamin K status were assessed in 21 preterm infants who were found to have an abnormal PT, despite 0.2-0.5 mg vitamin K1 prophylaxis at birth. Results: All infants had normal or supraphysiological vitamin K1 concentrations and undetectable or, in one infant, insignificant PIVKA-II, indicating adequate vitamin K status. Conclusion: In preterm infants born at < 32 wk gestation who received ≥ 0.2 mg vitamin K1 after delivery, a prolonged PT in the first month of life is unlikely to be due to vitamin K deficiency.

AB - Aim: To investigate the vitamin K status of preterm infants who have a prolonged prothrombin time (PT) in the first month of life. Methods: Measures of vitamin K status were assessed in 21 preterm infants who were found to have an abnormal PT, despite 0.2-0.5 mg vitamin K1 prophylaxis at birth. Results: All infants had normal or supraphysiological vitamin K1 concentrations and undetectable or, in one infant, insignificant PIVKA-II, indicating adequate vitamin K status. Conclusion: In preterm infants born at < 32 wk gestation who received ≥ 0.2 mg vitamin K1 after delivery, a prolonged PT in the first month of life is unlikely to be due to vitamin K deficiency.

KW - Phylloquinone

KW - PIVKA-II

KW - Premature

UR - https://www.scopus.com/pages/publications/31544431788

U2 - 10.1080/08035250500268233

DO - 10.1080/08035250500268233

M3 - Article

C2 - 16421045

AN - SCOPUS:31544431788

SN - 0803-5253

VL - 94

SP - 1822

EP - 1824

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

IS - 12

ER -

Vitamin K status of preterm infants with a prolonged prothrombin time

Abstract

Keywords

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