Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

Atreyee Mishra; Karrera Y. Djoko; Yi-Hsuan Lee; Rianne M. Lord; Grace Kaul; Abdul Akhir; Deepanshi Saxena; Sidharth Chopra; James W. Walton

doi:10.1039/D2OB01224C

Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

Atreyee Mishra, Karrera Y. Djoko, Yi-Hsuan Lee, Rianne M. Lord, Grace Kaul, Abdul Akhir, Deepanshi Saxena, Sidharth Chopra, James W. Walton

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Abstract

Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.

Original language	English
Pages (from-to)	2539-2544
Number of pages	6
Journal	Organic & Biomolecular Chemistry
Volume	21
Issue number	12
Early online date	1 Mar 2023
DOIs	https://doi.org/10.1039/D2OB01224C
Publication status	Published - 28 Mar 2023

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Cite this

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title = "Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity",

abstract = "Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.",

author = "Atreyee Mishra and Djoko, {Karrera Y.} and Yi-Hsuan Lee and Lord, {Rianne M.} and Grace Kaul and Abdul Akhir and Deepanshi Saxena and Sidharth Chopra and Walton, {James W.}",

note = "Funding Information: We acknowledge Durham University GCRF CDT for funding. We acknowledge Dmitry S. Yufit for crystallography and Emily R. Unsworth for ICP-OES. We also acknowledge the UKRI Future Leader Fellow scheme which fund the employment of Yi-Hsuan Lee and Rianne M. Lord at the University of East Anglia.",

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doi = "10.1039/D2OB01224C",

language = "English",

volume = "21",

pages = "2539--2544",

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TY - JOUR

T1 - Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

AU - Mishra, Atreyee

AU - Djoko, Karrera Y.

AU - Lee, Yi-Hsuan

AU - Lord, Rianne M.

AU - Kaul, Grace

AU - Akhir, Abdul

AU - Saxena, Deepanshi

AU - Chopra, Sidharth

AU - Walton, James W.

N1 - Funding Information: We acknowledge Durham University GCRF CDT for funding. We acknowledge Dmitry S. Yufit for crystallography and Emily R. Unsworth for ICP-OES. We also acknowledge the UKRI Future Leader Fellow scheme which fund the employment of Yi-Hsuan Lee and Rianne M. Lord at the University of East Anglia.

PY - 2023/3/28

Y1 - 2023/3/28

N2 - Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.

AB - Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.

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U2 - 10.1039/D2OB01224C

DO - 10.1039/D2OB01224C

M3 - Article

VL - 21

SP - 2539

EP - 2544

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

SN - 1477-0520

IS - 12

ER -

Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

Abstract

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