Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

Atreyee Mishra, Karrera Y. Djoko, Yi-Hsuan Lee, Rianne M. Lord, Grace Kaul, Abdul Akhir, Deepanshi Saxena, Sidharth Chopra, James W. Walton

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Abstract

Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.
Original languageEnglish
Pages (from-to)2539-2544
Number of pages6
JournalOrganic & Biomolecular Chemistry
Volume21
Issue number12
Early online date1 Mar 2023
DOIs
Publication statusPublished - 28 Mar 2023

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