TY - JOUR
T1 - Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea
AU - Lee, Kyungwon
AU - Kim, Mi-Na
AU - Choi, Tae Yeal
AU - Cho, Soung-Eun
AU - Lee, Seungok
AU - Whang, Dong Hee
AU - Yong, Dongeun
AU - Chong, Yunsop
AU - Woodford, Neil
AU - Livermore, David M.
PY - 2009/6
Y1 - 2009/6
N2 - Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-ß-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.
AB - Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-ß-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.
U2 - 10.1016/j.ijantimicag.2008.10.009
DO - 10.1016/j.ijantimicag.2008.10.009
M3 - Article
SN - 1872-7913
VL - 33
SP - 520
EP - 524
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 6
ER -