WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism

Victoria Sherwood; Shivendra Kumar Chaurasiya; Elin J Ekström; William Guilmain; Qing Liu; Thomas Koeck; Kate Brown; Karin Hansson; Margrét Agnarsdóttir; Michael Bergqvist; Karin Jirström; Fredrik Ponten; Peter James; Tommy Andersson

doi:10.1093/carcin/bgt390

WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism

Victoria Sherwood, Shivendra Kumar Chaurasiya, Elin J Ekström, William Guilmain, Qing Liu, Thomas Koeck, Kate Brown, Karin Hansson, Margrét Agnarsdóttir, Michael Bergqvist, Karin Jirström, Fredrik Ponten, Peter James, Tommy Andersson

Research output: Contribution to journal › Article

36 Citations (Scopus)

Abstract

WNT5A has been identified as an important ligand in the malignant progression of a number of tumours. Although WNT5A signalling is often altered in cancer, the ligand(')s role as either a tumour suppressor or oncogene varies between tumour types and is a contemporary issue for investigators of β-catenin (CTNNB1)-independent WNT signalling in oncology. Here we report that one of the initial effects of active WNT5A signalling in malignant melanoma cells is an alteration in cellular energy metabolism and specifically an increase in aerobic glycolysis. This was found to be at least in part due to an increase in active Akt signalling and lactate dehydrogenase (LDH) activity. The clinical relevance of these findings was strengthened by a strong correlation (p

Original language	English
Pages (from-to)	784-794
Number of pages	11
Journal	Carcinogenesis
Volume	35
Issue number	4
Early online date	30 Nov 2013
DOIs	https://doi.org/10.1093/carcin/bgt390
Publication status	Published - 2014

Access to Document

10.1093/carcin/bgt390

Cite this

Sherwood, V., Chaurasiya, S. K., Ekström, E. J., Guilmain, W., Liu, Q., Koeck, T., Brown, K., Hansson, K., Agnarsdóttir, M., Bergqvist, M., Jirström, K., Ponten, F., James, P., & Andersson, T. (2014). WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism. Carcinogenesis, 35(4), 784-794. https://doi.org/10.1093/carcin/bgt390

Sherwood, Victoria ; Chaurasiya, Shivendra Kumar ; Ekström, Elin J ; Guilmain, William ; Liu, Qing ; Koeck, Thomas ; Brown, Kate ; Hansson, Karin ; Agnarsdóttir, Margrét ; Bergqvist, Michael ; Jirström, Karin ; Ponten, Fredrik ; James, Peter ; Andersson, Tommy. / WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism. In: Carcinogenesis. 2014 ; Vol. 35, No. 4. pp. 784-794.

@article{71cfca616fef4fcda0afca320f7e35f5,

title = "WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism",

abstract = "WNT5A has been identified as an important ligand in the malignant progression of a number of tumours. Although WNT5A signalling is often altered in cancer, the ligand(')s role as either a tumour suppressor or oncogene varies between tumour types and is a contemporary issue for investigators of β-catenin (CTNNB1)-independent WNT signalling in oncology. Here we report that one of the initial effects of active WNT5A signalling in malignant melanoma cells is an alteration in cellular energy metabolism and specifically an increase in aerobic glycolysis. This was found to be at least in part due to an increase in active Akt signalling and lactate dehydrogenase (LDH) activity. The clinical relevance of these findings was strengthened by a strong correlation (p",

author = "Victoria Sherwood and Chaurasiya, {Shivendra Kumar} and Ekstr{\"o}m, {Elin J} and William Guilmain and Qing Liu and Thomas Koeck and Kate Brown and Karin Hansson and Margr{\'e}t Agnarsd{\'o}ttir and Michael Bergqvist and Karin Jirstr{\"o}m and Fredrik Ponten and Peter James and Tommy Andersson",

year = "2014",

doi = "10.1093/carcin/bgt390",

language = "English",

volume = "35",

pages = "784--794",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "4",

}

WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism. / Sherwood, Victoria; Chaurasiya, Shivendra Kumar; Ekström, Elin J; Guilmain, William; Liu, Qing; Koeck, Thomas; Brown, Kate; Hansson, Karin; Agnarsdóttir, Margrét; Bergqvist, Michael; Jirström, Karin; Ponten, Fredrik; James, Peter; Andersson, Tommy.

In: Carcinogenesis, Vol. 35, No. 4, 2014, p. 784-794.

Research output: Contribution to journal › Article

TY - JOUR

T1 - WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism

AU - Sherwood, Victoria

AU - Chaurasiya, Shivendra Kumar

AU - Ekström, Elin J

AU - Guilmain, William

AU - Liu, Qing

AU - Koeck, Thomas

AU - Brown, Kate

AU - Hansson, Karin

AU - Agnarsdóttir, Margrét

AU - Bergqvist, Michael

AU - Jirström, Karin

AU - Ponten, Fredrik

AU - James, Peter

AU - Andersson, Tommy

PY - 2014

Y1 - 2014

N2 - WNT5A has been identified as an important ligand in the malignant progression of a number of tumours. Although WNT5A signalling is often altered in cancer, the ligand(')s role as either a tumour suppressor or oncogene varies between tumour types and is a contemporary issue for investigators of β-catenin (CTNNB1)-independent WNT signalling in oncology. Here we report that one of the initial effects of active WNT5A signalling in malignant melanoma cells is an alteration in cellular energy metabolism and specifically an increase in aerobic glycolysis. This was found to be at least in part due to an increase in active Akt signalling and lactate dehydrogenase (LDH) activity. The clinical relevance of these findings was strengthened by a strong correlation (p

AB - WNT5A has been identified as an important ligand in the malignant progression of a number of tumours. Although WNT5A signalling is often altered in cancer, the ligand(')s role as either a tumour suppressor or oncogene varies between tumour types and is a contemporary issue for investigators of β-catenin (CTNNB1)-independent WNT signalling in oncology. Here we report that one of the initial effects of active WNT5A signalling in malignant melanoma cells is an alteration in cellular energy metabolism and specifically an increase in aerobic glycolysis. This was found to be at least in part due to an increase in active Akt signalling and lactate dehydrogenase (LDH) activity. The clinical relevance of these findings was strengthened by a strong correlation (p

U2 - 10.1093/carcin/bgt390

DO - 10.1093/carcin/bgt390

M3 - Article

C2 - 24293407

VL - 35

SP - 784

EP - 794

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 4

ER -