WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism

Victoria Sherwood; Shivendra Kumar Chaurasiya; Elin J Ekström; William Guilmain; Qing Liu; Thomas Koeck; Kate Brown; Karin Hansson; Margrét Agnarsdóttir; Michael Bergqvist; Karin Jirström; Fredrik Ponten; Peter James; Tommy Andersson

doi:10.1093/carcin/bgt390

WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism

Victoria Sherwood, Shivendra Kumar Chaurasiya, Elin J Ekström, William Guilmain, Qing Liu, Thomas Koeck, Kate Brown, Karin Hansson, Margrét Agnarsdóttir, Michael Bergqvist, Karin Jirström, Fredrik Ponten, Peter James, Tommy Andersson

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Abstract

WNT5A has been identified as an important ligand in the malignant progression of a number of tumours. Although WNT5A signalling is often altered in cancer, the ligand(')s role as either a tumour suppressor or oncogene varies between tumour types and is a contemporary issue for investigators of β-catenin (CTNNB1)-independent WNT signalling in oncology. Here we report that one of the initial effects of active WNT5A signalling in malignant melanoma cells is an alteration in cellular energy metabolism and specifically an increase in aerobic glycolysis. This was found to be at least in part due to an increase in active Akt signalling and lactate dehydrogenase (LDH) activity. The clinical relevance of these findings was strengthened by a strong correlation (p

Original language	English
Pages (from-to)	784-794
Number of pages	11
Journal	Carcinogenesis
Volume	35
Issue number	4
Early online date	30 Nov 2013
DOIs	https://doi.org/10.1093/carcin/bgt390
Publication status	Published - 2014

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Sherwood, V., Chaurasiya, S. K., Ekström, E. J., Guilmain, W., Liu, Q., Koeck, T., Brown, K., Hansson, K., Agnarsdóttir, M., Bergqvist, M., Jirström, K., Ponten, F., James, P., & Andersson, T. (2014). WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism. Carcinogenesis, 35(4), 784-794. https://doi.org/10.1093/carcin/bgt390

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AU - Sherwood, Victoria

AU - Chaurasiya, Shivendra Kumar

AU - Ekström, Elin J

AU - Guilmain, William

AU - Liu, Qing

AU - Koeck, Thomas

AU - Brown, Kate

AU - Hansson, Karin

AU - Agnarsdóttir, Margrét

AU - Bergqvist, Michael

AU - Jirström, Karin

AU - Ponten, Fredrik

AU - James, Peter

AU - Andersson, Tommy

PY - 2014

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DO - 10.1093/carcin/bgt390

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