WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism

Victoria Sherwood, Shivendra Kumar Chaurasiya, Elin J Ekström, William Guilmain, Qing Liu, Thomas Koeck, Kate Brown, Karin Hansson, Margrét Agnarsdóttir, Michael Bergqvist, Karin Jirström, Fredrik Ponten, Peter James, Tommy Andersson

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36 Citations (Scopus)

Abstract

WNT5A has been identified as an important ligand in the malignant progression of a number of tumours. Although WNT5A signalling is often altered in cancer, the ligand(')s role as either a tumour suppressor or oncogene varies between tumour types and is a contemporary issue for investigators of β-catenin (CTNNB1)-independent WNT signalling in oncology. Here we report that one of the initial effects of active WNT5A signalling in malignant melanoma cells is an alteration in cellular energy metabolism and specifically an increase in aerobic glycolysis. This was found to be at least in part due to an increase in active Akt signalling and lactate dehydrogenase (LDH) activity. The clinical relevance of these findings was strengthened by a strong correlation (p
Original languageEnglish
Pages (from-to)784-794
Number of pages11
JournalCarcinogenesis
Volume35
Issue number4
Early online date30 Nov 2013
DOIs
Publication statusPublished - 2014

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